... and membrane receptors have been identified as interacting proteins of eHsp90α and mediate its pro-metastasis function. However, the regulatory mechanism of eHsp90α activity remains largely unknown. Here, we report that clusterin, a protein newly demonstrated to interact with eHsp90α, modulates eHsp90α...

... expressed: growth arrest, senescence-associated β-galactosidase activity, senescence-associated gene overexpression, deletion in mitochondrial DNA. A set of 44 stress- and senescence-associated genes were found to be differentially expressed in this model, among which clusterin/apolipoprotein J (apo J...

...Laure Debure; Jean-Luc Vayssière; Vincent Rincheval; Fabien Loison; Yves Le Dréan; Denis Michel Clusterin is a puzzling protein upregulated in many diseased tissues,presented as either a survival or a death protein. The role of clusterin might depend on the final maturation and localization...

...Catherine Jomary; Gilles Chatelain; Denis Michel; Ann Weston; Michael J. Neal; Stephen E. Jones ABSTRACT Clusterin expression is increased in tissues undergoing apoptosis, including neurodegenerative retina, but the causal relationships remain to be clarified. To test the hypothesis...