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Keywords: clathrin
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Journal Articles
In collection:
Membrane trafficking
J Cell Sci (2024) 137 (8): jcs261674.
Published: 24 April 2024
...Stéphane Vassilopoulos; Guillaume Montagnac ABSTRACT Clathrin assembles into honeycomb-like lattices at the plasma membrane but also on internal membranes, such as at the Golgi and tubular endosomes. Clathrin assemblies primarily regulate the intracellular trafficking of different cargoes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (23): jcs259110.
Published: 6 December 2021
... are packaged into coated and non-coated transport carriers derived from the trans Golgi and TGN. The cargoes of clathrin-coated vesicles are chiefly residents of endo-lysosomal organelles, while uncoated carriers ferry cargo to the cell surface. There are outstanding questions regarding the mechanisms...
Includes: Supplementary data
Journal Articles
In collection:
Membrane trafficking
J Cell Sci (2021) 134 (19): jcs258587.
Published: 5 October 2021
... of the AP2 adaptor complex, a key player in clathrin-mediated endocytosis, is a highly organized process controlled by alpha- and gamma-adaptin-binding protein (AAGAB, also known as p34). In this study, we demonstrate that besides AP2, AAGAB also regulates the assembly of AP1, a cargo adaptor involved...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2021) 134 (3): jcs255794.
Published: 1 February 2021
...Ellis L. Ryan; James Shelford; Teresa Massam-Wu; Richard Bayliss; Stephen J. Royle ABSTRACT A multiprotein complex containing TACC3, clathrin and other proteins has been implicated in mitotic spindle stability. To disrupt this complex in an anti-cancer context, we need to understand its composition...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2020) 133 (17): jcs239681.
Published: 1 September 2020
...Francesco Baschieri; Dahiana Le Devedec; Samuel Tettarasar; Nadia Elkhatib; Guillaume Montagnac ABSTRACT Cells experience mechanical stresses in different physiological and pathological settings. Clathrin-coated structures (CCSs) are sensitive to such perturbations in a way that often results...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (13): jcs244467.
Published: 9 July 2020
... a role for clathrin and/or endocytosis in the regulation of this pathway, but conflicting results exist and demand a deeper mechanistic understanding. We investigated the consequences of clathrin depletion on Wnt/β-catenin signaling in cell lines and found a pronounced reduction in β-catenin protein...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (11): jcs240861.
Published: 4 June 2020
...Francesco Baschieri; Kseniia Porshneva; Guillaume Montagnac ABSTRACT Clathrin-mediated endocytosis is the main entry route for most cell surface receptors and their ligands. It is regulated by clathrin-coated structures that are endowed with the ability to cluster receptors and to locally bend...
Journal Articles
J Cell Sci (2019) 132 (20): jcs222992.
Published: 21 October 2019
... complex Clathrin Membrane traffic Endocytosis Golgi Hereditary spastic paraplegia Wellcome Trust 10.13039/100004440 086598 214272 Nearly a third of the proteins encoded by the human genome are predicted to be integral membrane proteins, all of which have to get to the right...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (16): jcs232868.
Published: 15 August 2019
..., that has been acquired in opisthokonts and missing in other organisms. We discuss how other multicellular organisms, such as plants, recognise ubiquitylated cargoes. Endocytosis Endosomal transport ESCRT Ubiquitin-binding domains Clathrin Deutsche Forschungsgemeinschaft 10.13039...
Journal Articles
J Cell Sci (2019) 132 (10): jcs224030.
Published: 15 May 2019
...Oxana M. Tsygankova; James H. Keen ABSTRACT Clathrin heavy chain is the structural component of the clathrin triskelion, but unique functions for the two distinct and highly conserved clathrin light chains (CLCa and CLCb, also known as CLTA and CLTB, respectively) have been elusive. Here, we show...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (21): jcs221317.
Published: 5 November 2018
... matrix adhesion. The vitronectin-binding integrin αVβ5 localizes to focal adhesions (FAs) as well as poorly characterized flat clathrin lattices (FCLs). Here, we show that, in human keratinocytes, αVβ5 is predominantly found in FCLs, and formation of the αVβ5-containing FCLs requires the presence...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (17): jcs216812.
Published: 3 September 2018
...Volker Haucke; Michael M. Kozlov ABSTRACT Clathrin-mediated endocytosis is an essential cellular mechanism by which all eukaryotic cells regulate their plasma membrane composition to control processes ranging from cell signaling to adhesion, migration and morphogenesis. The formation of endocytic...
Journal Articles
J Cell Sci (2018) 131 (1): jcs207696.
Published: 4 January 2018
...Wataru Yamamoto; Suguru Wada; Makoto Nagano; Kaito Aoshima; Daria Elisabeth Siekhaus; Junko Y. Toshima; Jiro Toshima ABSTRACT Clathrin-mediated endocytosis requires the coordinated assembly of various endocytic proteins and lipids at the plasma membrane. Accumulating evidence demonstrates a crucial...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2017) 130 (8): 1379–1392.
Published: 15 April 2017
...Paul T. Manna; Samson O. Obado; Cordula Boehm; Catarina Gadelha; Andrej Sali; Brian T. Chait; Michael P. Rout; Mark C. Field ABSTRACT Clathrin-mediated endocytosis (CME) is the most evolutionarily ancient endocytic mechanism known, and in many lineages the sole mechanism for internalisation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (13): 2625–2637.
Published: 1 July 2016
... pathway that directly returns cargo from early endosomes to the cell surface. In contrast, NECAP2 does not regulate the clathrin-mediated endocytosis of these cargos, the degradation of EGFR or the recycling of transferrin along the slow, Rab11-dependent recycling pathway. We show that protein knockdown...
Journal Articles
J Cell Sci (2015) 128 (24): 4588–4600.
Published: 15 December 2015
..., constituents of Glut4 storage vesicles (GSVs). We further found that CD2AP forms a complex with GGA2, a clathrin adaptor, which sorts Glut4 to GSVs, suggesting a role for CD2AP in this process. We also found that CD2AP forms a complex with clathrin and connects clathrin to actin in the perinuclear region...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2015) 128 (16): 3131–3142.
Published: 15 August 2015
... are important sorting stations for some retrograde cargo. SMAP2, a GTPase-activating protein (GAP) for Arf1 with a putative clathrin-binding domain, has previously been shown to participate in the retrograde transport of the cholera toxin B-subunit (CTxB) from recycling endosomes. Here, we found that clathrin...
Includes: Supplementary data