... a chemorepellent. Dictyostelium Chemotaxis Chemorepulsion Cytoskeleton Migration Phosphoinositide Phosphatidylinositol PTEN National Institutes of Health http://dx.doi.org/10.13039/100000002 GM118355 GM139486 Texas A&M University http://dx.doi.org/10.13039/100007904...

... interests. © 2023. Published by The Company of Biologists Ltd 2023 Summary: A Review on the current understanding of MAPK15-related atypical MAPK function and regulation, highlighting how studies in amoeba have provided information on atypical MAPK roles in chemotaxis and gene regulation...

...-8674(85)90036-4 Bosgraaf , L. , Russcher , H. , Smith , J. L. , Wessels , D. , Soll , D. R. and Van Haastert , P. J. (2002a). A novel cGMP signalling pathway mediating myosin phosphorylation and chemotaxis in Dictyostelium . EMBO J. 21 , 4560 - 4570 . 10.1093...

...-stimulated translocation of the GATA transcription factor GtaC as indicated by the distribution of a GFP–GtaC reporter. Erk2 was also found to be essential for the translocation of GtaC in response to external folate, a foraging signal that directs the chemotaxis of amoeba to bacteria. Erk1, the only other...

... at a late developmental stage in mouse embryos induced the irregular distribution of cardiomyocytes and misalignment of myofibrils, and reduced the heart size. Mechanistically, the expression of several genes involved in chemotaxis, including those in the CXCL12/CXCR4 and CCL2/CCR2/CCR4 pathways...

... report that mitochondrial outer membrane protein Mitofusin 2 (MFN2) regulates neutrophil homeostasis and chemotaxis in vivo . Mfn2 -deficient neutrophils are released from the hematopoietic tissue, trapped in the vasculature in zebrafish embryos, and not capable of chemotaxis. Consistent with this, human...

...Yuki Tanabe; Yoichiro Kamimura; Masahiro Ueda ABSTRACT In eukaryotic chemotaxis, parallel signaling pathways regulate the spatiotemporal pseudopod dynamics at the leading edge of a motile cell through the characteristic dynamics of an excitable system; however, differences in the excitability...

...Bhagawat C. Subramanian; Konstadinos Moissoglu; Carole A. Parent ABSTRACT Neutrophils sense and respond to diverse chemotactic cues through G-protein-coupled receptors (GPCRs). However, the precise trafficking dynamics of chemoattractant GPCRs during neutrophil activation and chemotaxis remain...

...-proteins and the cytoskeleton. Small G-proteins Cytoskeleton Symmetry Dictyostelium Chemotaxis Nederlandse Organisatie voor Wetenschappelijk Onderzoek 10.13039/501100005909 723.012.108 The nature of physics is symmetrical. For instance, molecules have equal probability...

... and chemical cues remains incompletely understood. Here, we address this question by probing the efficiency of epidermal growth factor (EGF)-induced hMSC chemotaxis on substrates of varying stiffness (3, 30 and 600 kPa) inside a polydimethylsiloxane (PDMS) microfluidic device. Chemotactic speed was found...

.... The cells break down LPA, which is present at high levels around the tumours, creating a dynamic gradient that is low in the tumour and high outside. They then migrate up this gradient, creating a complex and evolving outward chemotactic stimulus. Here, we introduce a new assay for self-generated chemotaxis...

... are not well understood. Here, we investigated the role of protein kinase A (PKA) in controlling signaling of the chemoattractant cAMP in Dictyostelium discoideum . We found that cells lacking PKA display severe chemotaxis defects, including impaired directional sensing. Although PKA is an important regulator...

... flow during the establishment of polarity. Actin flow Cell fusion Cell polarity Chemotaxis PTEN Ras Max-Planck-Gesellschaft 10.13039/501100004189 Deutsche Forschungsgemeinschaft 10.13039/501100001659 SFB 914, TP7 Orientation of eukaryotic cells...

...Inn Chuan Ng; Pornteera Pawijit; Lee Ying Teo; Huipeng Li; Shu Ying Lee; Hanry Yu ABSTRACT Chemotaxis in shallow gradients of chemoattractants is accomplished by preferential maintenance of protrusions oriented towards the chemoattractant; however, the mechanism of preferential maintenance...

... prognostic information for breast cancer patients. Circulating tumor cell CTC Chemotaxis Invadopodia Human invasion signature HIS Intravasation Mena Tumor microenvironment of metastasis TMEM National Cancer Institute 10.13039/100000054 1R01 CA170507-01 National...

..., as well as defects in chemotaxis directionality and adhesion to endothelial cells under flow. These data together elucidate a mechanism for RHOA and pMLC polarization in stimulated neutrophils through direct inhibition of RHOA by FAM65B at the leading edge. * These authors contributed equally...

... Filopodia Chemotaxis CAAX Lamellipodia initiate the migration of various cell types, ranging from fibroblasts and epithelial cells to different types of leukocytes (Small et al., 2002 ; Renkawitz and Sixt, 2010). Lamellipodia are composed of networks of actin filaments, directly connected in part...

...Arjan Kortholt; Ineke Keizer-Gunnink; Rama Kataria; Peter J. M. Van Haastert Summary Central to chemotaxis is the molecular mechanism by which a shallow spatial gradient of chemoattractant induces symmetry breaking of activated signaling molecules. Previously, we have used Dictyostelium mutants...

.... * Author for correspondence ([email protected]) 29 04 2013 © 2013. Published by The Company of Biologists Ltd 2013 RhoC GTPase p190RhoGAP p190RhoGEF Directional protrusion Chemotaxis Actin cytoskeleton Polarized protrusion of the cell toward a source...

...Adán Guerrero; Jesús Espinal; Christopher D. Wood; Juan M. Rendón; Jorge Carneiro; Gustavo Martínez-Mekler; Alberto Darszon Summary In many broadcast-spawning marine organisms, oocytes release chemicals that guide conspecific spermatozoa towards them through chemotaxis. In the sea urchin Lytechinus...