1-20 of 112
Keywords: chemotaxis
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
J Cell Sci (2023) 136 (20): jcs261447.
Published: 16 October 2023
... al., 2007 ). A broad range of proteins are downstream substrates of MAPKs, and phosphorylation of these proteins leads to many cellular responses that include mitogenic processes, cellular differentiation, directed cell growth (chemotrophy) and cell movement (e.g. chemotaxis). The mammalian MAPK3...
Journal Articles
In collection:
Cell migration
J Cell Sci (2023) 136 (3): jcs260591.
Published: 2 February 2023
.... , Smith , J. L. , Wessels , D. , Soll , D. R. and Van Haastert , P. J. ( 2002a ). A novel cGMP signalling pathway mediating myosin phosphorylation and chemotaxis in Dictyostelium . EMBO J. 21 , 4560 - 4570 . 10.1093/emboj/cdf438 Bosgraaf , L. , Russcher , H...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (16): jcs260148.
Published: 19 August 2022
...-stimulated translocation of the GATA transcription factor GtaC as indicated by the distribution of a GFP–GtaC reporter. Erk2 was also found to be essential for the translocation of GtaC in response to external folate, a foraging signal that directs the chemotaxis of amoeba to bacteria. Erk1, the only other...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (7): jcs259076.
Published: 1 April 2022
... at a late developmental stage in mouse embryos induced the irregular distribution of cardiomyocytes and misalignment of myofibrils, and reduced the heart size. Mechanistically, the expression of several genes involved in chemotaxis, including those in the CXCL12/CXCR4 and CCL2/CCR2/CCR4 pathways...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion , Organelles
J Cell Sci (2020) 133 (17): jcs248880.
Published: 4 September 2020
... report that mitochondrial outer membrane protein Mitofusin 2 (MFN2) regulates neutrophil homeostasis and chemotaxis in vivo . Mfn2 -deficient neutrophils are released from the hematopoietic tissue, trapped in the vasculature in zebrafish embryos, and not capable of chemotaxis. Consistent with this, human...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2018) 131 (18): jcs217422.
Published: 21 September 2018
...Bhagawat C. Subramanian; Konstadinos Moissoglu; Carole A. Parent ABSTRACT Neutrophils sense and respond to diverse chemotactic cues through G-protein-coupled receptors (GPCRs). However, the precise trafficking dynamics of chemoattractant GPCRs during neutrophil activation and chemotaxis remain...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (7): jcs208892.
Published: 9 April 2018
...-proteins and the cytoskeleton. Small G-proteins Cytoskeleton Symmetry Dictyostelium Chemotaxis Nederlandse Organisatie voor Wetenschappelijk Onderzoek 10.13039/501100005909 723.012.108 The nature of physics is symmetrical. For instance, molecules have equal probability...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (7): jcs211391.
Published: 6 April 2018
... and chemical cues remains incompletely understood. Here, we address this question by probing the efficiency of epidermal growth factor (EGF)-induced hMSC chemotaxis on substrates of varying stiffness (3, 30 and 600 kPa) inside a polydimethylsiloxane (PDMS) microfluidic device. Chemotactic speed was found...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (20): 3455–3466.
Published: 15 October 2017
.... The cells break down LPA, which is present at high levels around the tumours, creating a dynamic gradient that is low in the tumour and high outside. They then migrate up this gradient, creating a complex and evolving outward chemotactic stimulus. Here, we introduce a new assay for self-generated chemotaxis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (9): 1545–1558.
Published: 1 May 2017
... are not well understood. Here, we investigated the role of protein kinase A (PKA) in controlling signaling of the chemoattractant cAMP in Dictyostelium discoideum . We found that cells lacking PKA display severe chemotaxis defects, including impaired directional sensing. Although PKA is an important regulator...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2016) 129 (18): 3462–3472.
Published: 15 September 2016
... flow during the establishment of polarity. Actin flow Cell fusion Cell polarity Chemotaxis PTEN Ras Max-Planck-Gesellschaft 10.13039/501100004189 Deutsche Forschungsgemeinschaft 10.13039/501100001659 SFB 914, TP7 Orientation of eukaryotic cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (13): 2660–2672.
Published: 1 July 2016
...Inn Chuan Ng; Pornteera Pawijit; Lee Ying Teo; Huipeng Li; Shu Ying Lee; Hanry Yu ABSTRACT Chemotaxis in shallow gradients of chemoattractants is accomplished by preferential maintenance of protrusions oriented towards the chemoattractant; however, the mechanism of preferential maintenance...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (9): 1751–1758.
Published: 1 May 2016
... prognostic information for breast cancer patients. Circulating tumor cell CTC Chemotaxis Invadopodia Human invasion signature HIS Intravasation Mena Tumor microenvironment of metastasis TMEM National Cancer Institute 10.13039/100000054 1R01 CA170507-01 National...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (5): 992–1000.
Published: 1 March 2015
..., as well as defects in chemotaxis directionality and adhesion to endothelial cells under flow. These data together elucidate a mechanism for RHOA and pMLC polarization in stimulated neutrophils through direct inhibition of RHOA by FAM65B at the leading edge. * These authors contributed equally...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2013) 126 (19): 4502–4513.
Published: 1 October 2013
...Arjan Kortholt; Ineke Keizer-Gunnink; Rama Kataria; Peter J. M. Van Haastert Summary Central to chemotaxis is the molecular mechanism by which a shallow spatial gradient of chemoattractant induces symmetry breaking of activated signaling molecules. Previously, we have used Dictyostelium mutants...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (15): 3356–3369.
Published: 1 August 2013
.../jbc.M111.226431 King   J. S. , Insall   R. H. ( 2009 ). Chemotaxis: finding the way forward with Dictyostelium.   Trends Cell Biol.   19 , 523 – 530 . 10.1016/j.tcb.2009.07.004 Kusama   T. , Mukai   M. , Endo   H. , Ishikawa   O. , Tatsuta   M. , Nakamura   H. , Inoue   M...
Includes: Supplementary data
Journal Articles
Journal Articles