.... Published by The Company of Biologists Ltd 2023 Summary: Knockout of ErbB genes reveals that the ErbB1 and the ErbB2–ErbB3 complex mediate G1/S progression, and a ligand-independent ErbB2 activity is sufficient for preventing apoptosis at high cell density. ErbB EGF Cell proliferation...

...Nuria Andrés-Sánchez; Daniel Fisher; Liliana Krasinska ABSTRACT What do we know about Ki-67, apart from its usefulness as a cell proliferation biomarker in histopathology? Discovered in 1983, the protein and its regulation of expression and localisation throughout the cell cycle have been well...

..., cell proliferation and differentiation ( Cai et al., 1999 ; Joo et al., 2007 ; Mimnaugh et al., 2001 ; Yang et al., 2014 ). Increased dosage of USP16 (located on chromosome 21), as a consequence of gene triplication, has been shown to inhibit stem cell renewal and to promote cellular senescence...

... 19 2 2019 © 2019. Published by The Company of Biologists Ltd 2019 http://www.biologists.com/user-licence-1-1/ Summary: Deletion of TMEM30A in endothelial cells causes impaired cell proliferation, reduced tip cells and delayed vascular development toward the deep layers...

... lamins in wild-type cells increases cell proliferation, but in cells expressing progerin (a mutant lamin A that causes Hutchinson–Gilford progeria syndrome), low LAP2α levels result in proliferation defects. Here, the aim was to understand the molecular mechanism governing how relative levels of LAP2α...

... growth of wild-type epithelium. Mosaic loss of NMIIA and NMIIB combined with FGF signaling to induce hyperplasia. Mosaic analysis revealed that the cells that were null for both NMIIA and NMIIB, as well as wild-type cells, proliferated, indicating that the regulation of proliferation is both cell...

...-dependent manner. These observations reveal a new biological function of rRNA base methylation, which links ribosomal subunit formation to p53-dependent inhibition of cell proliferation in mammalian cells. * Present address: Laboratory for Genetic Code, Graduate School of Life and Medical Sciences...

... and enrichment of stem cell markers. Such CycE deregulation after Drp1 loss attenuates cell proliferation in low-cell-density environments. However, in high-cell-density environments, elevated MEK–ERK signaling in the absence of Drp1 releases mtCycE to support escape of contact inhibition and maintain aberrant...

... and C. elegans embryos, respectively, results in broadly similar phenotypes, but the timing and onset of these phenotypes is different. This could be due to differences in the developmental regulation of cell proliferation in the early embryos of these organisms. In Xenopus and zebrafish, Y RNAs...

... exemplify the convergence of ERK1/2 and mTOR signalling at eIF4E, and the key role of eIF4E downstream of mTOR in maintaining cell proliferation. They also have important implications for therapeutic strategies based around mTOR and the MEK1/2–ERK1/2 pathway. * These authors contributed equally...

... that are used to monitor or count mitochondrial abundance are not known, nor are the signalling pathways. Inhibiting the translation on mito-ribosomes genetically or with antibiotics can impair cell proliferation and has been attributed to defects in aerobic energy metabolism, even though proliferating cells...

...) and Pik3r1 (phosphatidylinositol 3-kinases regulatory 1) at both the mRNA and protein level. Overexpression of miR-128a in myoblasts inhibited cell proliferation by targeting IRS1. By contrast, inhibition of miR-128a induced myotube maturation and myofiber hypertrophy in vitro and in vivo . Moreover, our...

...Justin D. Mih; Aleksandar Marinkovic; Fei Liu; Asma S. Sharif; Daniel J. Tschumperlin Summary The stiffness of the extracellular matrix exerts powerful effects on cell proliferation and differentiation, but the mechanisms transducing matrix stiffness into cellular fate decisions remain poorly...

... 2012 Foxk1 Foxo4 Mef2 Cell proliferation Cell differentiation Adult skeletal muscle is a dynamic and highly regenerative tissue due to a resident myogenic progenitor cell (MPC) population ( Mauro, 1961 ). In response to a severe injury that involves more than 90% of the muscle, the MPC...

... the determination of cell fate to cell proliferation. Furthermore, increasing evidence supports the notion that this mechanism is conserved in mammals, where CIC has been implicated in cancer and neurodegeneration. In addition to summarizing our current knowledge on CIC, we also discuss the implications...

... ( Nguyen et al., 2010 ). * Author for correspondence ( [email protected] ) © 2012. 2012 CD98 Cell adhesion Cell proliferation Immunity Integrin All multicellular eukaryotic organisms initiate immune responses after recognizing common pathogen-associated molecular...

...-independent mechanism that links cell growth to cell proliferation in mammalian cells, and suggested that selective targeting of the RNA polymerase I transcription machinery might be advisable to hinder proliferation of p53-deficient cancer cells. Fig. 1. POLR1A RNAi selectively inhibits the rRNA...

...Paolo P. Provenzano; Patricia J. Keely The notion that cell shape and spreading can regulate cell proliferation has evolved over several years, but only recently has this been linked to forces from within and upon the cell. This emerging area of mechanical signaling is proving to be wide-spread...

... to this work ‡ Author for correspondence ( [email protected] ) 27 10 2010 © 2011. 2011 Trichoplein Microtubule (MT) Centriole Odf2 Ninein Cell proliferation Intermediate filaments (IFs), together with microtubules (MTs) and actin filaments, form the cytoskeletal...

... provide cues to cell proliferation, survival, differentiation and migration. Here, we show that α2β1 integrin, when ligated to the basement membrane component laminin-1, triggers a proliferation arrest in primary endothelial cells. Indeed, in the presence of strong growth signals supplied by growth...