...Pil Jung Kang; Rachel Mullner; Kendra Lian; Hay-Oak Park Cell polarization generally occurs along a single axis that is directed by a spatial cue. Cells of the budding yeast Saccharomyces cerevisiae undergo polarized growth and oriented cell division in a spatial pattern by selecting a specific bud...

.... Acid-base transport Cell polarity Cell–cell adhesion Scribble complex Primary cilium Mitosis Danmarks Frie Forskningsfond http://dx.doi.org/10.13039/501100011958 0135-0139B Finely tuned regulation of the subcellular localization of ion transport proteins is vital for tissue...

...Madhushalini Sukumar; Reagan DeFlorio; Chih-Yu Pai; David E. Stone ABSTRACT Cell polarization in response to chemical gradients is important in development and homeostasis across eukaryota. Chemosensing cells orient toward or away from gradient sources by polarizing along a front–rear axis. Using...

...Shengnan Zheng; Biyu Zheng; Zhenbang Liu; Xiaopeng Ma; Xing Liu; Xuebiao Yao; Wenfan Wei; Chuanhai Fu ABSTRACT Septins are a family of filament-forming GTP-binding proteins that regulate fundamental cellular activities, such as cytokinesis and cell polarity. In general, septin filaments function...

...: The Cdc42 guanine-nucleotide-exchange factor Cdc24 interacts with septins during bud site assembly. This interaction assists in recruiting septins and stabilizing Cdc24 at the incipient bud site. Cell polarity Protein–protein interaction SPLIFF Positive feedback Split-ubiquitin Yeast Cdc42...

... http://www.biologists.com/user-licence-1-1/ Summary: ATP11C-b, a C-terminal splice variant of the PS-flippase ATP11C, localizes to a limited region of the plasma membrane in polarized cells, and LLXY residues are critical for the localization. Cell polarity Membrane lipids Transporters...

... signaling hubs to promote cell polarization and actin nucleation. Here, we probe the nature of these domains using a variety of membrane- and actin cortex-associated probes. These data demonstrate that these domains are filopodia, which are stimulated transiently during polarity establishment and accumulate...

...Indrasen Magre; Vikas Fandade; Indraneel Damle; Poulomi Banerjee; Santosh Kumar Yadav; Mahendra Sonawane; Jomon Joseph ABSTRACT The Par polarity complex, consisting of Par3, Par6 and atypical protein kinase C (aPKC), plays a crucial role in the establishment and maintenance of cell polarity...

... on chemoattractant gradient detection in yeast, which occurs at a motile polarity patch. It further describes the stabilization and hyperpolarization process underlying cell fusion. Cell fusion Cell polarity Chemotropism Pheromone gradient Cdc42 MAPK S. cerevisiae S. pombe All cells...

... cells. Its depletion leads to apoptosis and DNA damage through separate mechanisms. Drosophila Cell polarity DNA damage PI3K Epithelium Neuroblast The polar localization of TnI prompted an analysis of well-characterized polarity proteins under TnI-deficient conditions...

...Kim J. A. Vendel; Sophie Tschirpke; Fayezeh Shamsi; Marileen Dogterom; Liedewij Laan ABSTRACT Cell polarity – the morphological and functional differentiation of cellular compartments in a directional manner – is required for processes such as orientation of cell division, directed cellular growth...

..., also known as STK10) or Ste20-like kinase (SLK). We also discuss how ezrin-binding scaffolding proteins regulate microvilli and how, despite these significant advances, it remains to be discovered how the cell polarity program ultimately interfaces with these processes. References Anniko , M...

...Ye Dee Tay; Marcin Leda; Andrew B. Goryachev; Kenneth E. Sawin ABSTRACT The conserved Rho-family GTPase Cdc42 plays a central role in eukaryotic cell polarity. The rod-shaped fission yeast Schizosaccharomyces pombe has two Cdc42 guanine nucleotide exchange factors (GEFs), Scd1 and Gef1, but little...

... their apical cell surface delivery to promote accurate tubulocyst formation. Galectin-3 β1-integrin Apical transport Endocytosis Cell polarity Epithelial cells maintain a polarized structure in which the apical membrane domain is separated by a tight junctional complex from the basolateral...

... on how cells read their own geometry, and the importance of these mechanisms in different physiological contexts. Cell shape Cytoskeleton Cell polarity Cell division Any biologist would acknowledge that cells are beautiful objects. The range of forms they span is not only aesthetic...

... of the daughter cells. Since most plasma membrane proteins are glycosylated, we determined the effect of attenuation of N-glycosylation on cell polarity. While polarity establishment was not perturbed, the size difference between the two cells formed in first cell division (AB and P1) was more variable in embryos...

.... Cell polarity Epithelial Cells Tight junctions Morphogenesis Lumen Formation The ability to form and expand lumens is an essential characteristic of epithelia within tubular organs, such as kidneys and intestines, and is indispensable to their function. Such lumens are lined by a monolayer...

... oocytes. RNA localization Molecular motor Cell polarity Actin Asymmetric protein sorting underlies the establishment and maintenance of cell polarity. Recent studies have revealed that mRNA localization is a prevalent mechanism used by different cell types for restricting protein...

...–M , see also Movie 4 ), similar to previous observations in proliferative zones of epithelial surfaces in mice ( Maliga et al., 2013 ). This could suggest that in addition to positioning the apical membrane, midbodies could have a role in lumen and cell polarity maintenance given that they persist...

... flow during the establishment of polarity. Actin flow Cell fusion Cell polarity Chemotaxis PTEN Ras Orientation of eukaryotic cells in a gradient of chemoattractant requires a signal processing system that translates an external gradient of signalling molecules, recognised...