... Competing interests The authors declare no competing or financial interests. 6 9 2022 30 6 2023 © 2023. Published by The Company of Biologists Ltd 2023 Summary: Trunk neural crest cell migration and fate decisions rely on glucose oxidation for energy production...

... of activating the SRC promoter in response to TGF-β. JUN, a member of the activator protein (AP)-1 family, localises to the enhancer and regulates TGF-β-induced SRC expression. Furthermore, TGF-β-induced SRC upregulation plays a crucial role in epithelial–mesenchymal transition (EMT)-associated cell migration...

... cells. PhD thesis, Georg-August Universität, Göttingen, Germany . Bodor , D. L. , Pönisch , W. , Endres , R. G. and Paluch , E. K. ( 2020 ). Of cell shapes and motion: the physical basis of animal cell migration . Dev. Cell 52 , 550 - 562 . 10.1016/j.devcel.2020.02.013...

... retain higher migration speed and focal adhesion dynamics over many generations as a result of a motility-related transcriptomic profile. Upregulated genes in isolated fast cells encoded integrin subunits, proto-cadherins and numerous other genes associated with cell migration. Dysregulation of several...

... a knock-sideways relocalisation approach, we were further able to confirm novel links between Rab11, Rab25 and the ESCPE-1 and retromer multiprotein sorting complexes, and identify new endocytic recycling machinery associated with Rab4, Rab11 and Rab25 that regulates cancer cell migration in the 3D matrix...

... 1 (Az 1 ) in a proteasome-mediated, ubiquitination-independent manner. Az1 absence leads to elevated EPLIN-β levels, causing enhanced cellular migration. Antizyme EPLIN Polyamines Ubiquitin-independent degradation Cell migration National Medical Research Council http://dx.doi.org...

... is limited. In vivo , progenitor cells directionally migrate from the surrounding loose mesenchyme towards regions of increasing matrix adherence (the condensation centers), which is accompanied by the upregulation of fibronectin. Here, we focused on the mechanisms of cell migration during mesenchymal cell...

...Akash Chinchole; Kaisar Ahmad Lone; Shweta Tyagi ABSTRACT Attainment of proper cell shape and the regulation of cell migration are essential processes in the development of an organism. The mixed lineage leukemia (MLL or KMT2A) protein, a histone 3 lysine 4 (H3K4) methyltransferase, plays...

... cell migration . Science 352 , 353 - 358 . 10.1126/science.aad7297 Dubik , N. and Mai , S. ( 2020 ). Lamin A/C: function in normal and tumor cells . Cancers (Basel) 12 , 3688 . 10.3390/cancers12123688 Gong , M. C. , Fuglsang , A. , Alessi , D...

...Jan Faix; Klemens Rottner ABSTRACT The tightly coordinated, spatiotemporal control of actin filament remodeling provides the basis of fundamental cellular processes, such as cell migration and adhesion. Specific protein assemblies, composed of various actin-binding proteins, are thought to operate...

... dynamic remodeling of the actin cytoskeleton. The WASP family verprolin homologous protein (WAVE) is a central Arp2/3 regulator driving lamellipodial protrusions and cell migration in most eukaryotic cells. Together with Abi, NCKAP1/Nap1, CYFIP/Sra-1 and BRK1/HSPC300, WAVE forms a conserved hetero...

... TRPML1 (also known as MCOLN1), enabling the local activation of myosin II at the cell rear. Taken together, our findings identify Rab7b as the missing physical link between lysosomes and the actomyosin cytoskeleton, allowing control of immune cell migration through lysosomal signaling. This article has...

... polymerization, cell migration and intracellular signaling. Loss of Rac2 activity leads to defects in neutrophil motility and chemotaxis in zebrafish ( Deng et al., 2011 ; Rosowski et al., 2016 ). However, it remains unknown whether Rac activation is restricted to the front of the cell during neutrophil...

...Zofia Ostrowska-Podhorodecka; Isabel Ding; Wilson Lee; Jelena Tanic; Sevil Abbasi; Pamma D. Arora; Richard S. Liu; Alison E. Patteson; Paul A. Janmey; Christopher A. McCulloch ABSTRACT Vimentin is a structural protein that is required for mesenchymal cell migration and directly interacts with actin...

.... and Discher , D. E. ( 2017 ). Mechanosensing by the nucleus: from pathways to scaling relationships . J. Cell Biol. 216 , 305 - 315 . 10.1083/jcb.201610042 Cooper , J. A. ( 2013 ). Mechanisms of cell migration in the nervous system . J. Cell Biol. 202 , 725 - 734 . 10.1083/jcb...

...Jie Liu; Zhongzhen Liu; Keng Chen; Wei Chen; Xiyuan Fang; Meng Li; Xuening Zhou; Ning Ding; Huan Lei; Chen Guo; Tao Qian; Yilin Wang; Lin Liu; Yonglong Chen; Hui Zhao; Ying Sun; Yi Deng; Chuanyue Wu ABSTRACT Cell migration involves front-to-rear asymmetric focal adhesion (FA) dynamics, which...

...Anna V. Samarelli; Tilman Ziegler; Alexander Meves; Reinhard Fässler; Ralph T. Böttcher ABSTRACT Integrin function depends on the continuous internalization of integrins and their subsequent endosomal recycling to the plasma membrane to drive adhesion dynamics, cell migration and invasion. Here we...

... spectrin binds to ankyrin, and these proteins function to regulate neural development. Cell migration Cytoskeleton Dendrite formation Membrane mechanics Spectrin Neural development The development of the nervous system requires the correct positioning of neurons and the accurate...

... (GR, also known as NR3C1) to regulate immunity, energy metabolism and tissue repair. Upon ligand binding, activated GR mediates cellular effects by regulating gene expression, but some GR effects can occur rapidly without new transcription. Here, we show that GCs rapidly inhibit cell migration...

... cytoplasmic protrusions and increased cell migration. EML4–ALK V3 also recruits the NEK9 and NEK7 kinases to microtubules via the N-terminal EML4 microtubule-binding region. Overexpression of wild-type EML4, as well as constitutive activation of NEK9, also perturbs cell morphology and accelerates migration...