... proteins mediate substrate targeting. However, in platelet-derived growth factor (PDGF)-induced signaling, Erk1/2 phosphorylate Pak1 to drive cell migration while remaining at the plasma membrane, raising the question of whether scaffolding proteins are required. Similarly, the small GTPase Arf-like...

... activity slows collective cell migration velocity in vivo , further suggesting that integrin-dependent adhesion and signaling contribute to metabolic changes. These data highlight an underexplored link between extracellular matrix (ECM)–integrin adhesion and metabolic activity in embryonic cell migration...

.... Recent studies have shown that Rab40 proteins play an important role in regulating cell migration, but the underlying mechanisms of how the Rab40–CRL5 complex functions are still not fully understood. In this study, we identified AMBRA1 as a novel binding partner of Rab40 GTPases and show...

...Cole Allan; Ovijit Chaudhuri ABSTRACT Cell migration occurs throughout development, tissue homeostasis and regeneration, as well as in diseases such as cancer. Cells migrate along two-dimensional (2D) surfaces or interfaces, within microtracks, or in confining three-dimensional (3D) extracellular...

... of IL-15 in modulating human natural killer (NK) cell migration on ICAM-1 or VCAM-1. We find eight behavioural subsets of NK cells based on their shape and migration dynamics between single timepoints, and four trajectories based on sequences of these behaviours over time. Therefore, by using cellPLATO...

...). However, more recently, we and others have demonstrated roles for MCT4 in cancer cell migration and invasiveness (Gallagher et al., 2009 ; Kong et al., 2016 ; Zhu et al., 2014). Although a role for MCT4 interaction with integrins has been proposed to favor cell migration (Gallagher et al., 2009...

...Mathilde Mathieu; Aleksi Isomursu; Johanna Ivaska ABSTRACT Cell migration is controlled by the coordinated action of cell adhesion, cytoskeletal dynamics, contractility and cell extrinsic cues. Integrins are the main adhesion receptors to ligands of the extracellular matrix (ECM), linking the actin...

... protrusions that mediate cell migration. Here, using knockdown (KD) or knockout (KO), we combine the inactivation of the Arp2/3 inhibitory protein arpin, the Arp2/3 subunit ARPC1A and the WAVE complex subunit CYFIP2, all of which enhance the polymerization of cortical branched actin. Inactivation of the three...

.... In silico modeling predicted facilitated cell migration into confining clefts independently of MMP activity, whereas migration into dense porous matrix was predicted to require matrix degradation. This prediction was verified experimentally, where inhibition of collagen degradation was found to strongly...

... Cell migration Fate decision Glycolysis Oxidative phosphorylation Bioenergetics Summary: Trunk neural crest cell migration and fate decisions rely on glucose oxidation for energy production and mobilize multiple cooperating metabolic pathways for their biosynthetic needs and execution...

... of activating the SRC promoter in response to TGF-β. JUN, a member of the activator protein (AP)-1 family, localises to the enhancer and regulates TGF-β-induced SRC expression. Furthermore, TGF-β-induced SRC upregulation plays a crucial role in epithelial–mesenchymal transition (EMT)-associated cell migration...

.... PhD thesis, Georg-August Universität, Göttingen, Germany . Bodor , D. L. , Pönisch , W. , Endres , R. G. and Paluch , E. K. (2020). Of cell shapes and motion: the physical basis of animal cell migration . Dev. Cell 52 , 550 - 562 . 10.1016/j.devcel.2020.02.013...

... retain higher migration speed and focal adhesion dynamics over many generations as a result of a motility-related transcriptomic profile. Upregulated genes in isolated fast cells encoded integrin subunits, proto-cadherins and numerous other genes associated with cell migration. Dysregulation of several...

... a knock-sideways relocalisation approach, we were further able to confirm novel links between Rab11, Rab25 and the ESCPE-1 and retromer multiprotein sorting complexes, and identify new endocytic recycling machinery associated with Rab4, Rab11 and Rab25 that regulates cancer cell migration in the 3D matrix...

... Antizyme EPLIN Polyamines Ubiquitin-independent degradation Cell migration Summary: EPLIN-β is degraded by ornithine decarboxylase antizyme 1 (Az 1) in a proteasome-mediated, ubiquitination-independent manner. Az1 absence leads to elevated EPLIN-β levels, causing enhanced cellular migration...

... is limited. In vivo , progenitor cells directionally migrate from the surrounding loose mesenchyme towards regions of increasing matrix adherence (the condensation centers), which is accompanied by the upregulation of fibronectin. Here, we focused on the mechanisms of cell migration during mesenchymal cell...

...Akash Chinchole; Kaisar Ahmad Lone; Shweta Tyagi ABSTRACT Attainment of proper cell shape and the regulation of cell migration are essential processes in the development of an organism. The mixed lineage leukemia (MLL or KMT2A) protein, a histone 3 lysine 4 (H3K4) methyltransferase, plays...

... calibration of nuclear stiffness. Cancer Metastasis Cell migration Cytoskeleton Nucleus Nuclear envelope Emerin Src Mechanotransduction Melanoma Research Alliance http://dx.doi.org/10.13039/100005190 688232 American Cancer Society http://dx.doi.org/10.13039/100000048...

...Jan Faix; Klemens Rottner ABSTRACT The tightly coordinated, spatiotemporal control of actin filament remodeling provides the basis of fundamental cellular processes, such as cell migration and adhesion. Specific protein assemblies, composed of various actin-binding proteins, are thought to operate...

... as a novel regulator of WAVE controlling cell shape and motility in immune response. Basal phosphorylation of WAVE by CK1α protects it from premature proteasomal degradation. Drosophila Macrophages Cell migration Cell shape Lamellipodia Cell motility Actin Arp2/3 WAVE CK1α CK2...