... that is linked to the regulation of growth factor signalling and tumour suppression. It is stabilized at the plasma membrane by trans homophilic interactions upon cell–cell contact. PTPRK regulates cell–cell adhesion but is also reported to regulate numerous cancer-associated signalling pathways. However...

... by The Company of Biologists Ltd 2024 Summary: A review of desmosome structure and assembly, highlighting recent insights into how desmosomes integrate signaling in the epidermis, and an overview of desmosomes as targets in human disease. Cell adhesion Cell mechanics Cytoskeleton Epidermal...

... factors found in animals and fungi. In the fission yeast Schizosaccharomyces pombe , they regulate various cellular processes, including cell cycle progression, lipid metabolism and cell adhesion. CSL proteins bind to DNA through their N-terminal Rel-like domain and central β-trefoil domain. Here, we...

...Mathilde Mathieu; Aleksi Isomursu; Johanna Ivaska ABSTRACT Cell migration is controlled by the coordinated action of cell adhesion, cytoskeletal dynamics, contractility and cell extrinsic cues. Integrins are the main adhesion receptors to ligands of the extracellular matrix (ECM), linking the actin...

... Cell adhesion Cell signaling National Institute of Arthritis and Musculoskeletal and Skin Diseases http://dx.doi.org/10.13039/100000069 R01AR070231 Stem cells reside in a specific microenvironment, or niche, which provides regulatory signals that sustain their stem cell...

.... and Brown , N. H. ( 2012 ). Cell adhesion in Drosophila: versatility of cadherin and integrin complexes during development . Curr. Opin. Cell Biol. 24 , 702 - 712 . 10.1016/j.ceb.2012.07.006 Charras , G. and Sahai , E. ( 2014 ). Physical influences of the extracellular...

... the current structural understanding of one key regulator of the focal adhesion complex, focal adhesion kinase (FAK), and how it communicates with mechanical parts to promote cellular movement. Cell adhesion Focal adhesion kinase FAK Structure Function Ministerio de Ciencia, Innovación y...

..., adhesive two-dimensional (2D)-migration and cell adhesion. We will also briefly highlight the potential relevance of Ena/VASP member phosphorylation, although concerning this topic and further detail, readers are mostly referred to several, excellent reviews ( Blanchoin et al., 2014 ; Drees and Gertler...

... Vestweber ABSTRACT Cadherin-mediated cell adhesion requires anchoring via the β-catenin–α-catenin complex to the actin cytoskeleton, yet, α-catenin only binds F-actin weakly. A covalent fusion of VE-cadherin to α-catenin enhances actin anchorage in endothelial cells and strongly stabilizes endothelial...

... to the underlying basement membrane. Integrin α6β4 is a receptor for laminins and plays a vital role in mediating cell adhesion by initiating the assembly of HDs. In addition, α6β4 has been implicated in signal transduction events that regulate diverse cellular processes, including proliferation and survival...

.... , Murray , J. , Chappuis-Flament , S. , Wong , E. , Gumbiner , B. M. and Shapiro , L. ( 2002 ). C-cadherin ectodomain structure and implications for cell adhesion mechanisms . Science 296 , 1308 - 1313 . 10.1126/science.1071559 Brand , A. H. and Perrimon , N...

..., influence cell adhesion properties ( Li et al., 1999 ; Schieber and Chandel, 2014 ). Indeed, quenching of ROS in Myo19-deficient cells leads to a recovery of focal adhesion numbers and morphology. Integrin-linked kinase (ILK), when located at focal adhesions, blocked the interaction of Miro1 with TRAK2...

.... PLEKHG4B Actin organization Cell adhesion Rho-GEF Myosin Annexin-A2 Japan Society for the Promotion of Science http://dx.doi.org/10.13039/501100001691 18K19280 24370051 23112005 20H03248 16K07335 20J12425 Japan Agency for Medical Research and Development http://dx.doi.org...

... of Biologists Ltd 2020 Summary: A Review of the mechanical tuning of growth factor signaling through crosstalk and interaction with mechanosensitive integrin cell adhesive receptors. EGFR Cancer Cell adhesion Integrin Mechanosensing Mechanotransduction Australian Government...

...-dependent suppression of PAR3 (encoded by PARD3 ) accelerates epithelial disorganization during early tumorigenesis. Diminished PAR3 led to loss of E-cadherin-mediated cell adhesion, which in turn contributed to misoriented cell division. Pharmacological inhibition of the MAPK pathway downstream of RAS...

... adhesions and invadopodia initiation and maturation, despite the differences in their morphology and functions. Cell adhesion Cell invasion Integrin adhesions Mechanosensing Focal adhesions Invadopodia Israel Science Foundation 10.13039/501100003977 Cell-matrix interactions...

...; Jinhua Wu; Vesa P. Hytönen; Bernhard Wehrle-Haller ABSTRACT Integrin activation and clustering by talin are early steps of cell adhesion. Membrane-bound talin head domain and kindlin bind to the β integrin cytoplasmic tail, cooperating to activate the heterodimeric integrin, and the talin head domain...

...Carolina Diaz; Stefanie Neubauer; Florian Rechenmacher; Horst Kessler; Dimitris Missirlis ABSTRACT The major fibronectin (FN)-binding α 5 β 1 and α v β 3 integrins exhibit cooperativity during cell adhesion, migration and mechanosensing, through mechanisms that are not yet fully resolved...

... cell adhesion. Some cytoplasmic cargo remains functional after transfer, as demonstrated with encapsidated genomes of measles virus (MeV). This virus uses nectin-4, but not nectin-1, as a receptor. Epithelial cells expressing nectin-4, but not those expressing another MeV receptor in its place, can...

... Boettner , B. and van Aelst , L. ( 2009 ). Control of cell adhesion dynamics by Rap1 signaling . Curr. Opin. Cell Biol.   21 , 684 - 693 . 10.1016/j.ceb.2009.06.004 Bos , J. L. , de Bruyn , K. , Enserink , J. , Kuiperij , B. , Rangarajan , S. , Rehmann , H...