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Keywords: cdc2
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Journal Articles
J Cell Sci (2008) 121 (6): 843–853.
Published: 15 March 2008
... be inactivated to permit exit from mitosis, licensing of replication origins and cytokinesis. To study the role of Cdc2p in greater detail, we generated a cdc2 allele that is sensitive to an inhibitory ATP analogue. We show that the inhibitor-induced cell cycle arrest is reversible and examine the effect...
Journal Articles
J Cell Sci (2007) 120 (2): 246–255.
Published: 15 January 2007
...In Sun Han; Tae Beom Seo; Kwan-Hoi Kim; Jin-Hwan Yoon; Sung-Jin Yoon; Uk Namgung Schwann cell migration facilitates peripheral nerve regeneration after injury. We have recently found increased activation of Cdc2 kinase in regenerating sciatic nerves. Here we show that Cdc2 phosphorylation...
Journal Articles
J Cell Sci (2006) 119 (2): 292–302.
Published: 15 January 2006
... of the cyclin-dependent kinase (Cdk) Cdc2 that regulates entry into mitosis. Studies of the cdc37 temperature-sensitive mutants show a genetic interaction with some cdc2 alleles and overexpression of cdc2 rescues the lethality of some cdc37 alleles at the restrictive temperature, suggesting that Cdc2...
Journal Articles
J Cell Sci (2005) 118 (11): 2485–2494.
Published: 01 June 2005
...Gilliane Maton; Thierry Lorca; Jean-Antoine Girault; René Ozon; Catherine Jessus The success of cell division relies on the activation of its master regulator Cdc2-cyclin B, and many other kinases controlling cellular organization, such as Aurora-A. Most of these kinase activities are regulated...
Journal Articles
J Cell Sci (2004) 117 (5): 701–710.
Published: 15 February 2004
... be phosphorylated in vitro by cell cycle kinases proximal to a putative nuclear localization signal (NLS), which substantiated a predicted casein kinase II (CKII)-cdc2 kinase-NLS (CcN) motif at position 180-239 and suggested that mSTI1 might move between the cytoplasm and the nucleus under certain cell cycle...
Journal Articles
J Cell Sci (1989) 1989 (Supplement_12): 9–19.
Published: 01 February 1989
...CAROLINE E. ALFA; ROBERT BOOHER; DAVID BEACH; JEREMY S. HYAMS Summary Entry into mitosis in the fission yeast Schizosaccharomyces pombe involves the interaction of a number of genes with the major cell cycle control gene, cdc2 + . One of these, cdc13 + , encodes a protein with homology to cyclin...
Journal Articles
J Cell Sci (1989) 1989 (Supplement_12): 65–76.
Published: 01 February 1989
... the transition between metaphase and anaphase (Hartwell, Key words: cell cycle, MPF, proteolysis, cdc2. 66 A. W. Murray G o Spindle correctly assembled? <30 Fig. 1. The somatic cell cycle in buddingyeast. The cell cycle is divided into four stages: G j, S, G 2 and M. The main points in the cell cycle where...
Journal Articles
J Cell Sci (1989) 1989 (Supplement_12): 39–51.
Published: 01 February 1989
... from starfish oocytes and its catalytic subunit identified as p34 cdc2 . M phase-promoting factor (MPF) was found to co-purify with the M phase-specific kinase throughout its purification. p34 cdc2 does not have to be associated with any specific protein for expression of H1 histone kinase or MPF...
Journal Articles
J Cell Sci (1989) 1989 (Supplement_12): 21–27.
Published: 01 February 1989
...GIULIO DRAETTA; DAVID BEACH Summary Recent experimental evidence has demonstrated the central role of the cdc2 protein kinase in the transition from G 2 to M phase in eukaryotic cells. We shall review our knowledge of the mechanisms which coordinate activation of the kinase with cell cycle-specific...