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Keywords: caspases
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Journal Articles
J Cell Sci (2007) 120 (7): 1189–1199.
Published: 01 April 2007
...David A. Primrose; Sidharth Chaudhry; A. George D. Johnson; Adam Hrdlicka; Anja Schindler; Dave Tran; Edan Foley Caspases are crucial activators of apoptosis and NF-κB signaling in vertebrates and invertebrates. In Drosophila , the caspase-9 counterpart Dronc is essential for most apoptotic death...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2005) 118 (14): 3091–3102.
Published: 15 July 2005
... transmembrane potential, caspase activation and chromatin condensation. While caspase inhibition retarded cell death, it had no protective effect on mitochondria. Stabilization of mitochondria by overexpression of Bcl-2 or the mitochondrion-targeted cytomegalovirus protein vMIA, however, blocked all signs of...
Journal Articles
J Cell Sci (2004) 117 (13): 2641–2651.
Published: 01 June 2004
... survival correlates with an inhibition of caspase activation and apoptosis that can, but does not always, depend upon their chaperoning activities. Several mechanisms proposed to account for these observations impact on both the `intrinsic', mitochondria-dependent and the `extrinsic', death-receptor...
Journal Articles
J Cell Sci (2003) 116 (3): 571–583.
Published: 01 February 2003
... caspases and that NuMA is cleaved coincidently with poly(ADP-ribose) polymerase-1 (PARP-1) and nuclear lamin B. NuMA is cleaved differently in Jurkat T and HeLa cells, suggesting that different sets of caspases are activated in these cell lines. The normal diffuse intranuclear distribution of NuMA changed...
Journal Articles
J Cell Sci (2002) 115 (24): 4727–4734.
Published: 15 December 2002
... proteins, apoptosis-inducing factor (AIF), is a phylogenetically old flavoprotein which, in healthy cells, is confined to the mitochondrial intermembrane space. Upon lethal signaling, AIF translocates, via the cytosol,to the nucleus where it binds to DNA and provokes caspase-independent chromatin...
Journal Articles
J Cell Sci (2002) 115 (23): 4671–4683.
Published: 01 December 2002
...Claudio A. Hetz; Martin Hunn; Patricio Rojas; Vicente Torres; Lisette Leyton; Andrew F. G. Quest Engagement of the Fas receptor promotes apoptosis by activation of caspases. In addition, alterations in plasma membrane lipid orientation and intracellular ceramide levels are often observed. In A20 B...