...Sang-Min Jang; Jung-Woong Kim; Daehwan Kim; Chul-Hong Kim; Joo-Hee An; Kyung-Hee Choi; Sangmyung Rhee Summary Caldesmon (CaD), which was originally identified as an actin-regulatory protein, is involved in the regulation of diverse actin-related signaling processes, including cell migration...

.... The dimerization domains form coiled-coil structures and serve as platforms for isoform-specific protein–protein interactions. Using the PKGIβ dimerization domain as an affinity probe in a proteomic screen, we identified the actin/myosin-associated protein caldesmon (CaD) as a PKGIβ-specific binding protein. PKGIβ...

... of caldesmon regulates Schwann cell migration and nerve regeneration. A robust but transient increase in Cdc2 expression was found in cultured Schwann cells prepared from the sciatic nerve in rats that had undergone crush injury for 7 days. These `injury-preconditioned' Schwann cells exhibited enhanced...

...Robert Eves; Bradley A. Webb; Shutang Zhou; Alan S. Mak Podosomes are highly dynamic actin-based structures commonly found in motile and invasive cells such as macrophages, osteoclasts and vascular smooth muscle cells. Here, we have investigated the role of caldesmon, an actin-binding protein...

...Yan Li; Jenny L. C. Lin; Rebecca S. Reiter; Karla Daniels; David R. Soll; Jim J. C. Lin Despite intensive in vitro studies, little is known about the regulation of caldesmon (CaD) by Ca 2+ -calmodulin (Ca 2+ -CaM) in vivo. To investigate this regulation, a mutant was generated of the C-terminal...

... gene, enhanced the affinity of TM-1 for F-actin, demonstrating different isoforms can act cooperatively on binding to actin. This effect was not detected with the other expressed β gene products. The presence of 83 kDa nonmuscle caldesmon was found to enhance the binding of TM-1 for F-actin...