..., including pathogens, for killing, digestion and antigen presentation. We present new insights into regulation of this process by Ca 2+ . Phagosome Lysosome Membrane fusion Calcium Pathogen Reconstitution Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659 HA 1929...

....287.5461.2185 Apáti , Á. , Jánossy , J. , Brózik , A. , Bauer , P. I. and Magócsi , M. ( 2003 ). Calcium induces cell survival and proliferation through the activation of the MAPK pathway in a human hormone-dependent leukemia cell line, TF-1* . J. Biol. Chem. 278 , 9235...

... MI1923/1-2 EXC-2049-390688087 SFB877/project Z2 SFB877/project B12 Microtubules Detyrosination Vasohibin Calcium Calpain Mass spectrometry Summary: Ca 2+ and the conventional calpains 1 and 2 regulate microtubule detyrosination. They could indirectly influence vasohibin activity...

.... © 2021. Published by The Company of Biologists Ltd 2021 Summary: An illustrated framework of the conceptual mainstays of Golgi sorting and export. Golgi Secretion Clathrin Glycoprotein Calcium Epithelial cells Lipids National Institutes of Health http://dx.doi.org...

... mechanism regulating the epithelial cell quiescence–proliferation decision is revealed by studies of a zebrafish model. Trpv6 Intracellular Ca 2+ ER Ca 2+ Calcium Calmodulin Cell cycle Ionocyte Zebrafish National Science Foundation http://dx.doi.org/10.13039/100000001 IOS-1557850...

... of genes encoding presenilin lead to familial forms of Alzheimer's disease. We propose the sea urchin embryo as a model to study the expression of presenilin Presenilin PSEN Sea urchin Development Mitosis Calcium Presenilins (PSENs) are transmembrane proteins that play both proteolysis...

... activation. Palmitoylation S-acylation Calcium Ca 2+ channel Orai1 Orai1 and STIM1 form Ca 2+ release-activated channels (CRAC), which are required for store-operated Ca 2+ entry (SOCE). Orai1, the pore-forming subunit of the CRAC channel ( Feske et al., 2006 ; Prakriya et al., 2006...

...., IDeA award to Dartmouth BioMT P20-GM113132, 5T32A1007519-22 to K.S.B.). Deposited in PMC for release after 12 months. References Bagur , R. and Hajnóczky , G. ( 2017 ). Intracellular Ca 2+ Sensing: its role in calcium homeostasis and signaling . Mol. Cell 66 , 780 - 788...

... Highlighted Article: PIEZO1 mechanically activated ion channels are enriched in the mouse mammary gland during lactation but are not essential for mammary epithelial cell function or post-lactational regression in vivo . Mammary gland PIEZO1 Ion channel Calcium Lactation Involution...

...Tom Cremer; Jacques Neefjes; Ilana Berlin ABSTRACT Calcium is the third most abundant metal on earth, and the fundaments of its homeostasis date back to pre-eukaryotic life forms. In higher organisms, Ca 2+ serves as a cofactor for a wide array of (enzymatic) interactions in diverse cellular...

... that mediate their divergent impacts on T cell activation. Vav2 Vav1 T cell Cdc42 Rac1 Calcium Ca 2+ American Heart Association 10.13039/100000968 0635546T National Institutes of Health 10.13039/100000002 R01 AI076575-01 R25 GM076321 T32 AI07077 The Vav family...

... of interaction with the functionally intact FKBP52 results in an increased TRPC3 activity and enhanced enlargement of cardiomyocytes. TRPC3 FKBP Calcineurin Calcium Cardiomyocyte The transient receptor potential (TRP; C-classical, TRPC) channels are tetrameric, non-selective ion channels...

... Summary: Calcium signaling leads a morphogenetic process during neural rosette formation by regulating the movement of cell cytoskeletal elements. Embryonic stem cells Neural stem cell niche Neural rosette formation Calcium Neurogenesis Adherens junctions Cytoskeleton proteins...

...+ release from the ER provides a functional link between the two organelles. Mitochondria Soluble adenylyl cyclase SAC Calcium IP3R Oxidative phosphorylation Cyclic AMP (cAMP) has been implicated in a wide variety of (often contradictory) physiological processes, including different...

... of Biologists Ltd 2016 Summary: Mice deficient in CNNM4, a Mg 2+ transporter, are infertile because this protein regulates sperm Ca 2+ homeostasis during the process of capacitation. Sperm capacitation Calcium Hyperactivation CNNM4 Sperm are maintained in an immotile state...

... biogenesis . J. Cell Biol.   187 , 247 - 264 . 10.1083/jcb.200907122 Docampo , R. and Moreno , S. N. J. ( 2011 ). Acidocalcisomes . Cell Calcium   50 , 113 - 119 . 10.1016/j.ceca.2011.05.012 Docampo , R. , Moreno , S. N. J. and Vercesi , A. E. ( 1993 ). Effect...

...://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. FACE Calcium Exocytosis Fusion pore Lamellar body Synaptotagmin Ca 2+ is the key element in regulated exocytosis controlling...

...Eulalia Pozo-Guisado; Vanessa Casas-Rua; Patricia Tomas-Martin; Aida M. Lopez-Guerrero; Alberto Alvarez-Barrientos; Francisco Javier Martin-Romero Summary STIM1 (stromal interaction molecule 1) is a key regulator of store-operated calcium entry (SOCE). Upon depletion of Ca 2+ concentration within...

... for correspondence ( helmut.plattner@uni-konstanz.de ) © 2013. Published by The Company of Biologists Ltd 2013 Ca 2+ Calcium Ca 2+ -release channels Protist Protozoa In metazoan cells, intracellular Ca 2+ -release channels (CRCs) are instrumental for local signalling on which specific membrane...

... and promotes its regulation of calcium-sensitive adenylyl cyclase type 8.   J. Biol. Chem.   286 , 32962 – 32975 . 10.1074/jbc.M111.243899 Dell’Acqua   M. L. , Faux   M. C. , Thorburn   J. , Thorburn   A. , Scott   J. D. ( 1998 ). Membrane-targeting sequences on AKAP79 bind...