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Keywords: cAMP
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Lipid biology
J Cell Sci (2023) 136 (22): jcs261563.
Published: 23 November 2023
... not additive, suggesting that they function in the same pathway. Increasing cAMP levels using a dunce mutant with reduced phosphodiesterase activity failed to rescue this impaired synaptic growth, suggesting that cholesterol functions downstream of cAMP. We used a protein kinase A (PKA) sensor to show...
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Journal Articles
J Cell Sci (2020) 133 (13): jcs245969.
Published: 9 July 2020
..., associated with an increase in intracellular cAMP levels. Real-time analysis of cAMP dynamics revealed that PI3Kγ modulates the degradation of cAMP in primary VSMCs independently of its kinase activity through regulation of the enzyme phosphodiesterase 4. Importantly, the use of an N-terminal competing...
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Organelles
J Cell Sci (2018) 131 (10): jcs215178.
Published: 16 May 2018
...Gergő Szanda; Éva Wisniewski; Anikó Rajki; András Spät ABSTRACT We have previously demonstrated in H295R adrenocortical cells that the Ca 2+ -dependent production of mitochondrial cAMP (mt-cAMP) by the matrix soluble adenylyl cyclase (sAC; encoded by ADCY10 ) is associated with enhanced aldosterone...
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J Cell Sci (2016) 129 (13): 2599–2612.
Published: 1 July 2016
...Miguel J. Lobo; Margarida D. Amaral; Manuela Zaccolo; Carlos M. Farinha ABSTRACT Cyclic AMP (cAMP) activates protein kinase A (PKA) but also the guanine nucleotide exchange factor ‘exchange protein directly activated by cAMP’ (EPAC1; also known as RAPGEF3). Although phosphorylation by PKA is known...
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Journal Articles
J Cell Sci (2014) 127 (23): 5115–5125.
Published: 1 December 2014
...Matthias Gerhardt; Michael Walz; Carsten Beta ABSTRACT Recent work has demonstrated that the receptor-mediated signaling system in chemotactic amoeboid cells shows typical properties of an excitable system. Here, we delivered spatially confined stimuli of the chemoattractant cAMP to the membrane...
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J Cell Sci (2014) 127 (19): 4172–4185.
Published: 1 October 2014
... specific AKAPs are depleted by siRNA-mediated knockdown, point to ezrin as a scaffold required for hCG-, cAMP- and PKA-mediated regulation of the fusion process. By a variety of immunoprecipitation and immunolocalization experiments, we show that ezrin directs PKA to a molecular complex of connexin 43...
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Journal Articles
J Cell Sci (2013) 126 (20): 4614–4626.
Published: 15 October 2013
... Dictyostelium , secreted cAMP serves as a chemoattractant, with extracellular cAMP propagated as oscillating waves to ensure directional migratory signals. cAMP oscillations derive from transient excitatory responses of adenylyl cyclase, which then rapidly adapts. We have studied chemotactic signaling...
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J Cell Sci (2012) 125 (4): 869–886.
Published: 15 February 2012
...Laura J. Ayling; Stephen J. Briddon; Michelle L. Halls; Gerald R. V. Hammond; Luis Vaca; Jonathan Pacheco; Stephen J. Hill; Dermot M. F. Cooper The central and pervasive influence of cAMP on cellular functions underscores the value of stringent control of the organization of adenylyl cyclases (ACs...
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J Cell Sci (2011) 124 (13): 2253–2266.
Published: 1 July 2011
... that cAMP-specific phosphodiesterases (PDE4s) directly bind PAFAH1B1 (also known as LIS1). Dissociation of LIS1–dynein complexes is coupled with loss of dynein function, as determined in assays of both microtubule transport and directed cell migration in wounded monolayers. Such loss in dynein functioning...
Journal Articles
J Cell Sci (2010) 123 (1): 107–117.
Published: 1 January 2010
...Debbie Willoughby; Sebastian Wachten; Nanako Masada; Dermot M. F. Cooper Ca 2+ -sensitive adenylyl cyclases (ACs) orchestrate dynamic interplay between Ca 2+ and cAMP that is a crucial feature of cellular homeostasis. Significantly, these ACs are highly selective for capacitative Ca 2+ entry (CCE...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (21): 3907–3914.
Published: 1 November 2009
... that is relayed to neighboring cells during chemotaxis. Although significant knowledge about cAMP production in chemotaxing cells has been derived from studies performed on cell populations, cAMP dynamics at the single cell level have not been investigated. To examine this, we used a FRET-based cAMP sensor...
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Journal Articles
J Cell Sci (2006) 119 (5): 828–836.
Published: 1 March 2006
... cyclic AMP (cAMP). A number of kinetic models (including our own) predict that interdependent Ca 2+ and cAMP oscillations can be generated. A previous study in Xenopus neurons illustrated prolonged, low-frequency cAMP oscillations during bursts of Ca 2+ transients. However, the detection of more dynamic...
Journal Articles
J Cell Sci (2006) 119 (3): 592–602.
Published: 1 February 2006
... Src cAMP Motility Skin The healing of cutaneous wounds is a dynamic, well-organized and complex process requiring the orchestration of many different cell types and cellular processes ( Martin, 1997 ). Dermal fibroblasts are actively involved in this process. They migrate to the wound site...