... matrix, translating mechanical cues into biochemical signals. Moreover, vessels require the capability to enzymatically degrade the matrix surrounding them, to facilitate vascular expansion. c-Src plays a key role in blood vessel growth, with its loss in the endothelium reducing vessel sprouting...

... adherens junction integrity, as manifested by defective E-cadherin accumulation and peri-junctional F-actin density. These effects correlate with a role for RPTPα in cellular (c)-Src activation at sites of E-cadherin engagement. Mechanistically, RPTPα is required for appropriate tyrosine phosphorylation...

... activator of ERK1/2. In contrast, PKCα was involved in ERK1/2 activation because inhibition of its activity prevented ERK1/2 phosphorylation. The tyrosine kinase c-Src also contributed to ERK1/2 activation, however, it did not interact with PKCα in the same molecular complex. The α V β 3 /PKCα complex...

... proposed in addition to the one at the genomic level. Estrogen has been described to activate c-Src kinase and this activation has been shown to be responsible for estrogen-dependent mitogenicity. A major substrate of c-Src kinase activity is the cytoskeletal protein p130Cas, originally identified in v-Src...

... influences these processes. The current study was performed to establish whether p190RhoGAP directly participates in epidermal growth factor-induced actin stress fiber disassembly and how c-Src is involved in this process. Our results support a model in which the p190 MD negatively regulates the activity...

... and activation of the adhesion kinase PYK2 and the adaptor protein p130 Cas in a Src-dependent manner. The objective of this study was to analyse the role of c-Src in the α v β 3 integrin-dependent recruitment of signalling and cytoskeletal molecules in osteoclasts during bone resorption. Using prefusion...

...Thérèse David-Pfeuty; Shubha Bagrodia; David Shalloway ABSTRACT Myristoylation of pp60 src is required for its membrane attachment and transforming activity. The mouse monoclonal antibody, mAb327, which recognizes both normal, myristoylated pp60 c-src and a nonmyristoylated mutant, pp60 c-src/myr...

...Gabrielle Meyerson; Karl H. Pfenninger; Sven Påhlman ABSTRACT Nerve growth cones of primary neurons are highly enriched in the proto-oncogene product pp60 c-src . In order to investigate this molecule further in growing neuronal cells, growth cone and cell body fractions were prepared from human SH...