... promotes axonal regeneration and tissue homeostasis. Transition into a repair phenotype requires expression of c-Jun and Sox2, which transcriptionally mediates inhibition of the dSC program of myelination and activates a non-cell-autonomous repair program, characterized by the secretion of neuronal...

... was induced in severed retinal ganglion cells and was also expressed in bystander Müller glia. Cell-type-specific deletion of transactivating RelA in neurons and/or macroglia stimulated axonal regeneration in a distinct and synergistic pattern. By contrast, deletion of the p50 suppressor subunit promoted...

...David Tonge; Kevin Chan; Ning Zhu; Aliza Panjwani; Mathew Arno; Steven Lynham; Malcolm Ward; Alison Snape; John Pizzey Axonal regeneration is enhanced by the prior `conditioning' of peripheral nerve lesions. Here we show that Xenopus dorsal root ganglia (DRG) with attached peripheral nerves (PN-DRG...

... a role for this pathway in peripheral axonal growth. Cdc2 upregulation in migrating Schwann cells suggests functional association with axonal regeneration. To delineate the role of Cdc2 in axonal regeneration after injury, neurite outgrowth of DRG sensory neurons in the presence of Schwann cells...

... and Vanselow, 1990 ). In addition to the grafting, 5 μl of the protease inhibitor/dexamethasone solution ( Table 1 ) were injected into the vitreous body of the operated eye. Labelling of the ganglion cells whose axons regenerated into the grafts was performed 4 weeks later, when growing axons were considered...