... in cells. This observation may help to explain the generation of anti-centrosome autoantibodies in certain autoimmune patients and may be important for centrosome function. For some studies, anti-pericentrin-B antibodies were purified directly from the human anti-centrosome serum. For these experiments...

...Takami Maekawa; Ryoko Kuriyama ABSTRACT Using a human autoantibody, SP-H, we identified a 200-230 kDa mitotic MAP in a variety of mammalian cell lines which shows affinity for the minus end of microtubules and also becomes associated with the spindle pole during mitosis. To examine the detailed...