... and pathological processes, such as blood coagulation, neurodegeneration, cell–cell fusion and viral infection. However, the mechanisms through which it regulates these processes remain largely elusive. Using endothelial cell-mediated angiogenesis as a model, here we report a previously unknown intracellular...

... FAs. As reduction in cell–cell junction integrity has been shown to increase migratory capacity and sprouting angiogenesis (Bentley et al., 2014), our data suggest that a balanced control of both cell–matrix and cell–cell junctions is essential for mediating migration. When migratory capacity...

...Aukie Hooglugt; Miesje M. van der Stoel; Apeksha Shapeti; Beau F. Neep; Annett de Haan; Hans van Oosterwyck; Reinier A. Boon; Stephan Huveneers ABSTRACT Angiogenesis is a tightly controlled dynamic process demanding a delicate equilibrium between pro-angiogenic signals and factors that promote...

...William R. Critchley; Gina A. Smith; Ian C. Zachary; Michael A. Harrison; Sreenivasan Ponnambalam ABSTRACT Vascular endothelial growth factor receptor 2 (VEGFR2, encoded by KDR) regulates endothelial function and angiogenesis. VEGFR2 undergoes ubiquitination that programs this receptor...

...Yao Xiao; Mingliang Li; Teng Ma; Hao Ning; Libo Liu ABSTRACT AMG232 effectively inhibits cancers with wild-type p53 (also known as TP53) by reactivating p53, but whether it inhibits glioma angiogenesis remains unclear. This study confirms that AMG232 inhibits the proliferation of glioma endothelial...

...Julian Rapp; Malte Jung; Rhena F. U. Klar; Julian Wolf; Jakob Arnold; Oliver Gorka; Olaf Groß; Clemens Lange; Hansjürgen Agostini; Günther Schlunck; Felicitas Bucher ABSTRACT Aberrant angiogenesis is a hallmark of cardiovascular and retinal neovascular disease. The STAT3 signaling pathway...

...Wenjing Liu; Xiaoyan Jiang; Xiao Li; Kuanxiang Sun; Yeming Yang; Mu Yang; Shujin Li; Xianjun Zhu ABSTRACT Precise Norrin and β-catenin (Norrin/β-catenin; encoded by NDP and CTNNB1 , respectively) signaling is critical for proper angiogenesis. Dysregulation of this signaling leads to various...

...Kiyomi Tsuji-Tamura; Saori Morino-Koga; Shingo Suzuki; Minetaro Ogawa ABSTRACT Elongation of vascular endothelial cells (ECs) is an important process in angiogenesis; however, the molecular mechanisms remain unknown. The actin-crosslinking protein TAGLN (transgelin, also known as SM22 or SM22α...

... development and embryonic lethality. Although hypoxia is implicated in vascular remodelling and angiogenesis, its effect on PTP-PEST remains unexplored. Here we report that hypoxia (1% oxygen) increases protein levels and catalytic activity of PTP-PEST in primary endothelial cells. Immunoprecipitation...

... with GEF activities that binds many proteins including the GAP Git1, have been identified (Liu et al., 2012). Mutations in zebrafish arhgef7 or itgb8 give rise to pathological angiogenesis and cerebral edema (Liu et al., 2012), although the exact mechanisms underlying these vascular pathologies remain...

...Hao Xu; Kevin Pumiglia; Susan E. LaFlamme ABSTRACT During angiogenesis, endothelial cells engage components of the extracellular matrix through integrin-mediated adhesion. Endothelial expression of laminin-411 and laminin-511 is known to promote vessel stability. However, little is known about...

...Jordi Lambert; Kate Makin; Sophia Akbareian; Robert Johnson; Abdullah A. A. Alghamdi; Stephen D. Robinson; Dylan R. Edwards ABSTRACT ADAMTS-1 is an extracellular protease with critical roles in organogenesis and angiogenesis. Here we demonstrate a functional convergence of ADAMTS-1...

... YAP/TAZ (YAP is also known as YAP1, and TAZ as WWTR1) signaling is crucial for sprouting angiogenesis and vascular homeostasis. However, the underlying molecular mechanisms that explain how YAP/TAZ control the vasculature remain unclear. This study reveals that the focal adhesion protein deleted...

... a window on the pathological angiogenic and fibrotic response to suture implantation and how this can be modulated by genetically or pharmacologically dampening inflammation. Angiogenesis Fibrosis Foreign body Inflammation Wound Zebrafish Wellcome Trust 10.13039/100010269 WT097791...

... vascular angiogenesis, which is a fundamental process in vascular development. Our data indicate that knockdown of TMEM30A in primary human retinal endothelial cells led to reduced tube formation. In mice, endothelial cell (EC)-specific deletion of Tmem30a led to retarded retinal vascular development...

...Julienne Chaqour; Sangmi Lee; Aashreya Ravichandra; Brahim Chaqour ABSTRACT Abscisic acid (ABA) has shown anti-inflammatory and immunoregulatory properties in preclinical models of diabetes and inflammation. Herein, we studied the effects of ABA on angiogenesis, a strictly controlled process...

... is a key feature in tumour blood vessel stabilisation and pericyte recruitment, processes that are important in the growth and maturation of tumour blood vessels. However, the role of pericyte α6β1-integrin in angiogenesis is largely unknown. We developed mice where the α6-integrin subunit is deleted...

...Xiaolei Liang; Lina Zhang; Shihua Wang; Qin Han; Robert Chunhua Zhao ABSTRACT Angiogenesis plays crucial roles in various physiological processes including wound healing and tissue repair. It requires a tight interaction between endothelial cells and their surrounding environment. Mesenchymal stem...

... © 2016. Published by The Company of Biologists Ltd 2016 Summary: Activator of G-protein signaling 8 (AGS8) regulates the angiogenic events in endothelial cells by influencing the intracellular distribution of VEGFR-2. A new signal input to angiogenesis by AGS8 is suggested...

...Jui M. Dave; Colette A. Abbey; Camille L. Duran; Heewon Seo; Gregory A. Johnson; Kayla J. Bayless ABSTRACT During angiogenesis, endothelial cells must coordinate matrix proteolysis with migration. Here, we tested whether the focal adhesion scaffold protein Hic-5 (also known as TGFB1I1) regulated...