... not only regulates alternative splicing in the heart but also the formation of circRNAs. * Author for correspondence ([email protected]) Handling Editor: Maria Carmo-Fonseca Competing interests Y.M.P. is an inventor on patents, holds minor shares (<5%), and serves...

... sarcomere organization and stiffness. The titin gene (TTN) is subject to various alternative splicing events, but in the region that is present at the M-line, the only exon that can be spliced out is Mex5, which encodes for the insertion sequence 7 (is7). Interestingly, in the heart, the majority of titin...

... and axon growth. The eukaryotic Ccd42 gene is alternatively spliced to generate mRNAs with two different 3′ untranslated regions (UTRs) that encode proteins with distinct C-termini. The C-termini of these Cdc42 proteins include CaaX and CCaX motifs for post-translational prenylation and palmitoylation...

... Cellular fibronectin (FN; also known as FN1) variants harboring one or two alternatively spliced so-called extra domains (EDB and EDA) play a central bioregulatory role during development, repair processes and fibrosis. Yet, how the extra domains impact fibrillar assembly and function of the molecule...

...Alexander Neumann; Magdalena Schindler; Didrik Olofsson; Ilka Wilhelmi; Annette Schürmann; Florian Heyd ABSTRACT Alternative splicing (AS) strongly increases proteome diversity and functionality in eukaryotic cells. Protein secretion is a tightly controlled process, especially when it occurs...

... biogenesis, not by controlling the transcription of CeHD-related genes, but by affecting the alternative splicing of unc-52 (known as perlecan or HSPG2 in mammals), the predicted basement extracellular matrix (ECM) ligand of CeHDs. CCAR-1 physically interacts with HRP-2 (hnRNPR in mammals), a splicing factor...

... how trafficking pathways are fine-tuned for specialized tissue functions in vivo and during development. In parallel, the ENCODE project and numerous genetic studies have revealed that alternative splicing regulates gene expression in tissues and throughout development at a post-transcriptional level...

...) granules. RNP granules assemble through a concentration-dependent liquid–liquid phase separation of RNA-binding proteins that contain low-complexity sequence domains (LCDs). Interestingly, many factors that regulate microRNA (miRNA) biogenesis and alternative splicing are RNA-binding proteins that contain...

...) Competing interests The authors declare no competing or financial interests. 1 08 2014 15 12 2014 © 2015. Published by The Company of Biologists Ltd 2015 Mef2 Muscle differentiation Rbfox Alternative splicing Together with transcriptional control, alternative splicing...

.... , Jørgensen   A. L. , Nielsen   A. L. (2007). Regulatory mechanisms for 3′-end alternative splicing and polyadenylation of the Glial Fibrillary Acidic Protein, GFAP, transcript.   Nucleic Acids Res.   35 , 7636 – 7650 . Boyd   S. E. , Nair   B. , Ng   S. W. , Keith   J. M. , Orian...

...Sita Subbaram; Scott P. Lyons; Kimberly B. Svenson; Sean L. Hammond; Lorena G. McCabe; Sridar V. Chittur; C. Michael DiPersio ABSTRACT It is unknown how cues from the tumor microenvironment can regulate post-transcriptional mechanisms, such as alternative splicing, that control genes that drive...

...Erin A. Greaves; Nikki A. Copeland; Dawn Coverley; Justin F. X. Ainscough CIZ1 is a nuclear-matrix-associated DNA replication factor unique to higher eukaryotes, for which alternatively spliced isoforms have been associated with a range of disorders. In vitro, the CIZ1 N-terminus interacts...

... all known types of alternative splicing, the most common being alternative splicing of cassette exons. We confirmed that knockdown of Son leads to exon skipping in pre-mRNAs for chromatin-modifying enzymes, including ADA, HDAC6 and SetD8. This study reports a comprehensive view of human transcription...

...Natacha Dreumont; Cyril F. Bourgeois; Fabrice Lejeune; Yilei Liu; Ingrid E. Ehrmann; David J. Elliott; James Stévenin RBMY is a male germline RNA binding protein and potential alternative splicing regulator, but the lack of a convenient biological system has made its cellular functions elusive. We...

...). Here, we identified and characterized another four claudin-10 splice variants in mouse and human. One (Cldn10a_v1) results from an alternative splice donor site, causing a deletion of the last 57 nucleotides of exon 1a. For each of these three variants one further splice variant was identified...

...). The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines. Cancer Res. 60 , 3872 -3879. Fang, M., Li, J., Blauwkamp, T., Bhambhani, C., Campbell, N. and Cadigan, K. M. (2006). C-terminal...

... of variants. Sequence analysis identified at least six variants that result from alternative splicing and intron retention. Comparison of the results of perlecan RT-PCR analysis with those of analysis of four other genes suggested that the splicing defect in the perlecan gene is unique...

.... They are predicted to contain ten membrane-spanning segments, two large cytoplasmic loops as well as cytosolic N- and C-termini. Several isoform variants are generated for both PMCA1 and PMCA2 by alternative splicing, affecting their first cytosolic loop (A-site) and their C-terminal tail. To understand how...

...Anabella Srebrow; Alberto R. Kornblihtt Alternative splicing is a crucial mechanism for generating protein diversity. Different splice variants of a given protein can display different and even antagonistic biological functions. Therefore, appropriate control of their synthesis is required...

... arrested at G2 phase has a temperature-sensitive ubiquitin-activating enzyme, E1. J. Biol. Chem. 263 , 15726 -15731. Lee, C., Atanelov, L., Modrek, B. and Xing, Y. (2003). ASAP: the alternative splicing annotation project. Nucleic Acids Res. 31 , 101 -105. Longart, M., Liu, Y., Karavanova...