.../ Highlighted Article: Gene-modification experiments in mice show that co-expression of the testis-specific sperm membrane proteins CMTM2A and CMTM2B is required for fertilization. CKLF CMTM gene cluster CRISPR/Cas9 Fertilization Testis Zona pellucida Chemokines are secreted proteins...

...Maria Jimenez-Movilla; Jurrien Dean The zona pellucida contains three proteins (ZP1, ZP2, ZP3), the precursors of which possess signal peptides, ‘zona’ domains and short (9–15 residue) cytoplasmic tails downstream of a transmembrane domain. The ectodomains of ZP2 and ZP3 are sufficient to form...

...Philip C. N. Chiu; Man-Kin Chung; Riitta Koistinen; Hannu Koistinen; Markku Seppala; Pak-Chung Ho; Ernest H. Y. Ng; Kai-Fai Lee; William S. B. Yeung Fertilization depends on successful binding of the spermatozoa to the zona pellucida of the oocyte. Glycodelin-A inhibits spermatozoa-zona pellucida...

... the process of acrosome reaction (AR) triggered by the zona pellucida, according to a cyclic AMP-dependent pathway triggered by CB1R activation. Furthermore, activation of TRPV1 receptors seems to play a role of stabilization of the plasma membranes in capacitated sperm, as demonstrated by the high incidence...

... of Biologists 1996 Mouse Oogenesis Fertilization Zona pellucida Antisense oligonucleotide Targeted mutagenesis Null mutation Until now, there has been relatively little information available about how the mammalian egg extracellular coat, the zona pellucida (ZP), assembles during oogenesis...