... levels is critical. In Caenorhabditis elegans , the anaphase-promoting complex/cyclosome and its co-activator FZR-1 (APC/C FZR-1 ), a ubiquitin ligase, negatively regulates centrosome assembly through SAS-5 degradation. In this study, we report the C. elegans ZYG-1 (Plk4 in humans) as a potential...

... is mediated by the F-box protein Slimb/βTrCP. We show that levels of the C. elegans Plk4 homolog ZYG-1 are elevated by impairing proteasome or SCF function, indicating that ZYG-1 is regulated by a conserved mechanism. In C. elegans , similar to Drosophila and humans, we find that the Slimb/βTrCP homolog LIN...

... differently during the two modes of division. In Caenorhabditis elegans , the kinase ZYG-1 plays an essential role in both mitotic and meiotic centriole duplication. We have found that the C-terminus of ZYG-1 is necessary and sufficient for targeting to centrosomes and is important for differentiating mitotic...