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Keywords: ZO-1
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Journal Articles
J Cell Sci (2021) 134 (18): jcs253468.
Published: 17 September 2021
... role in the CCM of invasive human colorectal cancer (CRC) epithelium by modulating leading-edge cell dynamics in 2D. The extracellular pool of PLP2, secreted via exosomes, was also found to contribute to the event. During CCM, the protein was found to exist in association with ZO-1 (also known as TJP1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (3): jcs208736.
Published: 05 February 2018
... unexplored. Here, we examine the role of tight junctions during cytokinesis in the epithelium of the Xenopus laevis embryo. Depletion of the tight junction-associated proteins ZO-1 and GEF-H1 leads to altered cytokinesis duration and contractile ring geometry. Using a tension biosensor, we show...
Includes: Supplementary data
Journal Articles
In collection:
J Cell Sci (2017) 130 (23): 4013–4027.
Published: 01 December 2017
... spectrometry, the MT2-MMP cytosolic tail was found to interact with the zonula occludens protein-1 (ZO-1) at the apical junctions of polarized epithelial cells. Functionally, MT2-MMP localizes in the apical domain of epithelial cells where it cleaves E-cadherin and promotes epithelial cell accumulation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (20): 4396–4408.
Published: 15 October 2014
... tight junction assembly and epithelial cell differentiation through modulation of the ZO-1–ZONAB pathway. CFTR colocalizes with ZO-1 at the tight junctions of trachea and epididymis, and is expressed before ZO-1 in Wolffian ducts. CFTR interacts with ZO-1 through the CTFR PDZ-binding domain. In a three...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (5): 1104–1116.
Published: 01 March 2014
...Alice E. Zemljic-Harpf; Joseph C. Godoy; Oleksandr Platoshyn; Elizabeth K. Asfaw; Anna R. Busija; Andrea A. Domenighetti; Robert S. Ross ABSTRACT Vinculin (Vcl) links actin filaments to integrin- and cadherin-based cellular junctions. Zonula occludens-1 (ZO-1, also known as TJP1) binds connexin-43...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (17): 3904–3915.
Published: 01 September 2013
... upon neighboring epithelial cells binding to one another and forming adherens junctions, but the mechanism for how these processes are linked is poorly understood. Using a knockdown and substitution system, we studied whether ZO-1 binding to α-catenin is required for coupling tight junction assembly...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (24): 4069–4078.
Published: 15 December 2008
...)-binding proteins are known to be involved in endocytic internalization of gap junctions. Here, we analyzed the discrete molecular interactions that occur between Src, ZO-1 and Cx43 during Cx43 internalization in response to the non-genomic carcinogen γ-hexachlorocyclohexane (HCH). Internalization...
Journal Articles
J Cell Sci (2007) 120 (16): 2838–2850.
Published: 15 August 2007
... of tight junctions only. In Ca 2+ -switch experiments on MDCK cells, ZO-1 (also known as TJP1) preceded GFP-tagged shroom2 at the differentiating tight junctions. ZO-1 directly interacts with the serine- and proline-rich region of shroom2 in vitro. Moreover, the two proteins colocalize in vivo at mature...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (9): 1505–1511.
Published: 01 May 2007
.... Balda, M. S. and Matter, K. ( 2000 ). The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression. EMBO J. 19 , 2024 -2033. Balda, M. S. and Matter, K. ( 2003 ). Epithelial cell adhesion and the regulation of gene expression. Trends Cell Biol. 13...
Journal Articles
J Cell Sci (2006) 119 (10): 2095–2106.
Published: 15 May 2006
... expression increases myosin light chain phosphorylation, reorganizes perijunctional F-actin, and increases tight junction permeability. TJ proteins ZO-1 and occludin are markedly redistributed, morphologically and biochemically, but effects on claudin-1 and claudin-2 are limited. tMLCK inhibition prevents...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (10): 2167–2176.
Published: 15 May 2005
...James G. Laing; Brian C. Chou; Thomas H. Steinberg ZO-1 is the major connexin-interacting protein in ROS 17/2.8 (ROS) osteoblastic cells. We examined the role of ZO-1 in Cx43-mediated gap junction formation and function in ROS cells that expressed the connexin-interacting fragment of ZO-1 (ROS/ZO...
Journal Articles
J Cell Sci (2004) 117 (7): 1247–1257.
Published: 01 March 2004
... with endogenous claudins. Co-culture experiments, as well as electron microscopy, revealed that the two apposed membranes of TJs were not detached, but co-endocytosed into one of the adjacent cells. Interestingly, other TJ components such as occludin, JAM and ZO-1 appeared to be dissociated from claudins before...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2003) 116 (19): 3879–3891.
Published: 01 October 2003
... that the tight junction-associated protein ZO-1 associates with JAM-2/-3 in a PDZ domain-dependent manner. Using ectopic expression of JAM-2 in CHO cells, we show that the junctional localization of JAM-2 is regulated by serine phosphorylation and that its clustering at cell-cell contacts recruits endogenous PAR...
Journal Articles
J Cell Sci (1993) 1993 (Supplement_17): 119–125.
Published: 01 December 1993
... intercellular junctions tight junction zonula occludens ZO-1 cingulin desmosome © The Company of Biologists Limited 1993 1993 Journal o f Cell Science, Supplem ent 17, 119-125 (1993) Printed in G reat Britain © The Company o f Biologists Limited 1993 119 Biogenesis of structural intercellular...