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Keywords: XBP1
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Journal Articles
J Cell Sci (2019) 132 (5): jcs217216.
Published: 15 February 2019
... are expressed ubiquitously ( Ishikawa et al., 2011 ). In response to ER stress, IRE1 gains activity to splice the mRNA of X-box-binding protein 1 (XBP1) to induce the expression of stress response genes, analogous to what occurs with Hac1 mRNA in yeast ( Cox and Walter, 1996 ; Calfon et al., 2002 ; Shen et...
Journal Articles
J Cell Sci (2017) 130 (18): 3040–3049.
Published: 15 September 2017
...Huai-Wei Huang; Xiaomei Zeng; Taiyoun Rhim; David Ron; Hyung Don Ryoo ABSTRACT IRE1 mediates the unfolded protein response (UPR) in part by regulating XBP1 mRNA splicing in response to endoplasmic reticulum (ER) stress. In cultured metazoan cells, IRE1 also exhibits XBP1-independent biochemical...
Includes: Supplementary data
Journal Articles
Journal Articles
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Lipid biology
J Cell Sci (2009) 122 (10): 1626–1636.
Published: 15 May 2009
... set of signaling mechanisms triggered by increased demands on the protein folding capacity of the ER. The UPR transcriptional activator X-box binding protein 1 (XBP1) regulates the expression of proteins that function throughout the secretory pathway and is necessary for development of an expansive ER...
Includes: Supplementary data