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Keywords: Wound healing
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Journal Articles
In collection:
Adhesion , Cytoskeleton , Polarity
J Cell Sci (2025) 138 (5): JCS263674.
Published: 12 March 2025
... , J. A. ( 2013 ). Regulation of cytoskeletal organization and junctional remodeling by the atypical cadherin Fat . Development 140 , 433 - 443 . 10.1242/dev.083949 Martin , P. and Lewis , J. ( 1992 ). Actin cables and epidermal movement in embryonic wound healing...
Includes: Supplementary data
Journal Articles
J Cell Sci (2024) 137 (16): jcs262202.
Published: 29 August 2024
...-inflammatory phenotype and altering their regulation of angiogenesis, collagen deposition and re-epithelialization during skin wound healing, as well as dampening osteoblast and osteoclast recruitment and bone mineralization during fracture repair. For infected skin wounds, R848-reprogrammed macrophages...
Includes: Supplementary data
Journal Articles
In collection:
Cell biology and disease
J Cell Sci (2020) 133 (19): jcs235838.
Published: 12 October 2020
... investigated how topical insulin application would affect the diabetic wound healing process. We found that the excessive expression of insulin-degrading enzyme led to insufficient insulin levels in diabetic skin during wound healing, which ultimately reduced the recovery rate of diabetic wounds. We confirmed...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (13): jcs227900.
Published: 10 July 2020
... factor activation Tissue repair Wound healing Myofibroblasts were first described in healing rat wound granulation tissue by Gabbiani and co-workers as cells that share morphological features of “ conventional tissue fibroblasts ” and contractile smooth muscle cells by being “ capable...
Includes: Supplementary data
Journal Articles
In collection:
Cell biology and disease
J Cell Sci (2019) 132 (18): jcs234633.
Published: 23 September 2019
...Kristin J. Lastwika; Clarence A. Dunn; Joell L. Solan; Paul D. Lampe ABSTRACT The gap junction protein connexin 43 (Cx43) is a key player in wound healing, and inhibitors of Cx43, which speed epidermal wound healing, are currently in clinical trials. Here, we provide direct in vivo evidence...
Includes: Supplementary data
Journal Articles
In collection:
Cell migration
J Cell Sci (2018) 131 (17): jcs213595.
Published: 3 September 2018
.... Grainy head Epithelia Wound healing E-Cadherin Cytoskeleton Fundação para a Ciência e a Tecnologia SFRH/BD/60401/2009 SFRH/BPD/84569/2012 PD/BD/106058/2015 Human Frontier Science Program 10.13039/100004412 RGP/2007 European Research Council 10.13039/100010663...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Adhesion
J Cell Sci (2017) 130 (20): 3481–3495.
Published: 15 October 2017
... healing. Myofibroblast Integrin Fibrosis Scarring Wound healing Research to Prevent Blindness 10.13039/100001818 Office for Extramural Research, National Institutes of Health 10.13039/100006955 T32 GM 062754 R01 EY024942 Tissue scarring and fibrotic disease...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (5): 975–988.
Published: 1 March 2017
... H 2 O 2 -dependent oxidation of the inhibitor of κB kinase α and de-repression of epidermal growth factor promoter activity stimulates keratinocyte migration. Wound repair Wound healing Keratinocytes Migration Reactive oxygen species Hydrogen peroxide H 2 O 2 IKKα Sulfenylation EGF...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (4): 774–787.
Published: 15 February 2016
... Summary: The focal adhesion protein Hic-5 plays a crucial role in myofibroblast differentiation in response to TGF-β by facilitating tension-dependent stress fiber assembly and MRTF-A nuclear accumulation. Hic-5 MRTF-A Mechanotransduction Myofibroblast Fibrosis Wound healing In normal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (8): 1475–1480.
Published: 15 April 2015
... and HSP90AB1, respectively) work together to promote cell motility in wounded skin and accelerate wound closure. We demonstrate that Hsp90α and Hsp90β have distinct and non‐exchangeable functions during wound healing. Under hypoxia and when there is a lack of serum factors, Hsp90β binds to the cytoplasmic tail...
Journal Articles
J Cell Sci (2014) 127 (19): 4159–4171.
Published: 1 October 2014
...Hiroya Takada; Kishio Furuya; Masahiro Sokabe ABSTRACT Cutaneous wound healing is accelerated by exogenous mechanical forces and is impaired in TRPC6-knockout mice. Therefore, we designed experiments to determine how mechanical force and TRPC6 channels contribute to wound healing using HaCaT...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (12): 2709–2722.
Published: 15 June 2014
... as the percentage of migration relative to control cells. For scratch wound healing assays, NIH-3T3, HeLa, Arl13b hnn or wild-type MEFs were grown to confluence and the monolayer scratched using 200 µl pipette plastic tips. After washing once with PBS, DMEM supplemented with 0.5% BSA was added together with PDGF...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (8): 1829–1839.
Published: 15 April 2014
...Vasilios Tsarouhas; Liqun Yao; Christos Samakovlis ABSTRACT Metazoans have evolved efficient mechanisms for epidermal repair and survival following injury. Several cellular responses and key signaling molecules that are involved in wound healing have been identified in Drosophila...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (21): 5005–5017.
Published: 1 November 2013
...Jingjing Li; Siwei Zhang; Ximena Soto; Sarah Woolner; Enrique Amaya Summary Embryonic wound healing provides a perfect example of efficient recovery of tissue integrity and homeostasis, which is vital for survival. Tissue movement in embryonic wound healing requires two functionally distinct actin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (11): 2381–2391.
Published: 1 June 2013
... characterised, including the extracellular-signal-regulated kinases (ERKs) 1 and 2. In a small interfering RNA (siRNA)-based high-throughput wound healing screen performed in A549 lung carcinoma cells, we identified ERK2 but not ERK1 as a strong mediator of HGF-induced motility. This finding was confirmed...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (7): 1703–1712.
Published: 1 April 2013
... to be important for co-ordinating cellular responses during wound healing ( Kretz et al., 2003 ) and it has been proposed that Cx30 may play a crucial role ( Coutinho et al., 2003 ) in those events. Mice with ablation of the gene ( Gjb6 ) that encodes Cx30 (Cx30 null mice) are long-lived, breed and show...
Journal Articles
J Cell Sci (2012) 125 (23): 5667–5676.
Published: 1 December 2012
...Amanda R. Brock; Yan Wang; Susanne Berger; Renate Renkawitz-Pohl; Violet C. Han; Yujane Wu; Michael J. Galko Summary Injury is an inevitable part of life, making wound healing essential for survival. In postembryonic skin, wound closure requires that epidermal cells recognize the presence of a gap...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (17): 3929–3937.
Published: 1 September 2012
... attracted the attention of researchers in other fields, as new functions of activin in angiogenesis, inflammation, immunity, fibrosis and cancer have been discovered. Studies from our laboratory have identified activin as a crucial regulator of wound healing and skin carcinogenesis. On the one hand...
Journal Articles
J Cell Sci (2012) 125 (13): 3075–3083.
Published: 1 July 2012
.... * Authors for correspondence ( [email protected] ; [email protected] ) © 2012. Published by The Company of Biologists Ltd 2012 Activin Cancer Tumor microenvironment Wound healing Cells and tissues respond to a variety of mechanical stresses that can be roughly classified as follows: (1...