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Keywords: Wnt signaling
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J Cell Sci (2023) 136 (20): jcs261214.
Published: 27 October 2023
..., is degraded through tankyrase. Consequently, tankyrase small-molecule inhibitors block Wnt signaling by stabilizing axin, revealing potential for cancer therapy. Here, we discovered that axin is phosphorylated by casein kinase 1 alpha 1 (CSNK1A1, also known as CK1α) at an N-terminal casein kinase 1 consensus...
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Series: REVIEW COMMONS TRANSFER
J Cell Sci (2021) 134 (24): jcs259383.
Published: 20 December 2021
...Jia Yu; Pei-Ju Liao; Weijun Xu; Julie R. Jones; David B. Everman; Heather Flanagan-Steet; Thomas H. Keller; David M. Virshup ABSTRACT Wnt signaling is essential for normal development and is a therapeutic target in cancer. The enzyme PORCN, or porcupine, is a membrane-bound O -acyltransferase...
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J Cell Sci (2021) 134 (3): jcs249375.
Published: 1 February 2021
... of PGCs greatly limits their application. Studies have shown that the formation of mammalian PGCs is induced by BMP4 signal, but the mechanism underlying chicken PGC formation has not been determined. Here, we confirmed that Wnt signaling activated via BMP4 activates transcription of Lin28A by inducing β...
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J Cell Sci (2020) 133 (13): jcs244467.
Published: 9 July 2020
.... 24 1 2020 4 6 2020 © 2020. Published by The Company of Biologists Ltd 2020 http://www.biologists.com/user-licence-1-1/ Highlighted Article: The exocytic function of clathrin controls the abundance of the Wnt signaling component β-catenin through LRP5/6 and cadherin...
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J Cell Sci (2018) 131 (1): jcs207316.
Published: 4 January 2018
... by its ATPase activity and also by CK1 peptides. CK1 biosensor Protein Ser/Thr kinase RNA helicase DDX3 Activating kinase subunit Medulloblastoma Wnt signaling European Molecular Biology Organization 10.13039/100004410 Schweizerischer Nationalfonds zur Förderung der...
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J Cell Sci (2017) 130 (11): 1890–1903.
Published: 1 June 2017
... in colon cancer, it was later shown to regulate planar cell polarity (PCP) and directional cell movement. PTK7 is a Wnt co-receptor; however, its role in Wnt signaling remains controversial. Here, we find evidence that places PTK7 at the intersection of canonical and non-canonical Wnt signaling pathways...
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Journal Articles
J Cell Sci (2017) 130 (9): 1532–1544.
Published: 1 May 2017
...-canonical’ due to their limited ability to activate β-catenin when expressed alone, unexpectedly, we find that multiple Wnt combinations can synergistically activate β-catenin signaling in multiple cell types. WNT1- and WNT7B-mediated synergistic Wnt signaling requires FZD5, FZD8 and LRP6, as well...
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Journal Articles
J Cell Sci (2016) 129 (4): 693–705.
Published: 15 February 2016
.... ( 2010 ). The role of wnt signaling in physiological and pathological angiogenesis . Circ. Res.   107 , 943 - 952 . 10.1161/CIRCRESAHA.110.223750 Delgado , V. M. C. , Nugnes , L. G. , Colombo , L. L. , Troncoso , M. F. , Fernandez , M. M. , Malchiodi , E. L. , Frahm...
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J Cell Sci (2014) 127 (22): 4857–4869.
Published: 15 November 2014
... elevated LRP6 protein levels and activated Wnt/β-catenin signaling, whereas overexpression of Vldlr suppressed Wnt signaling. Moreover, we demonstrate that the VLDLR ectodomain is essential and sufficient for inhibition of Wnt signaling. The VLDLR ectodomain accelerated internalization and degradation...
Journal Articles
J Cell Sci (2014) 127 (18): 3970–3982.
Published: 15 September 2014
.../by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Wnt signaling Development Endocytosis Signalosome Zebrafish Wnt/β-Catenin signaling is an essential, evolutionarily conserved pathway...
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J Cell Sci (2013) 126 (10): 2213–2224.
Published: 15 May 2013
... a novel function of Bmal1 in controlling myogenic differentiation through direct transcriptional activation of components of the canonical Wnt signaling cascade, a major inductive signal for embryonic and postnatal muscle growth. Genetic loss of Bmal1 in mice leads to reduced total muscle mass and Bmal1...
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J Cell Sci (2013) 126 (9): 2060–2068.
Published: 1 May 2013
... showed that norrin is a vertebrate ortholog for insect burs and pburs and stimulates Wnt signaling mediated by LGR4, but not by LGR5 and 6, in mammalian cells. Although norrin could only activate LGR4, binding studies suggested interactions between norrin and LGR4, 5 and 6. Norrin, the Norrie disease...
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Journal Articles
J Cell Sci (2012) 125 (22): 5288–5301.
Published: 15 November 2012
...Gabriela Valls; Montserrat Codina; Rachel K. Miller; Beatriz Del Valle-Pérez; Meritxell Vinyoles; Carme Caelles; Pierre D. McCrea; Antonio García de Herreros; Mireia Duñach Summary A role for Rac1 GTPase in canonical Wnt signaling has recently been demonstrated, showing that it is required for β...
Includes: Supplementary data
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J Cell Sci (2011) 124 (14): 2357–2366.
Published: 15 July 2011
... suggested that other growth factors have important roles in controlling SSC fate. Because β-catenin-dependent Wnt signaling promotes self-renewal of various stem cell types, we hypothesized that this pathway contributes to SSC maintenance. Using transgenic reporter mice for β-catenin-dependent signaling, we...
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Journal Articles
J Cell Sci (2010) 123 (1): 23–28.
Published: 1 January 2010
...Ryohei Katayama; Toshiyasu Ishioka; Shinji Takada; Ritsuko Takada; Naoya Fujita; Takashi Tsuruo; Mikihiko Naito Cellular FLIP (cFLIP) inhibits the apoptosis signaling initiated by death receptor ligation. We previously reported that a long form of cFLIP (cFLIP-L) enhances Wnt signaling via...
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Journal Articles
J Cell Sci (2008) 121 (11): 1793–1802.
Published: 1 June 2008
...Jolita Hendriksen; Marnix Jansen; Carolyn M. Brown; Hella van der Velde; Marco van Ham; Niels Galjart; G. Johan Offerhaus; Francois Fagotto; Maarten Fornerod The standard model of Wnt signaling specifies that after receipt of a Wnt ligand at the membranous receptor complex, downstream mediators...
Includes: Supplementary data