..., is degraded through tankyrase. Consequently, tankyrase small-molecule inhibitors block Wnt signaling by stabilizing axin, revealing potential for cancer therapy. Here, we discovered that axin is phosphorylated by casein kinase 1 alpha 1 (CSNK1A1, also known as CK1α) at an N-terminal casein kinase 1 consensus...

...Jia Yu; Pei-Ju Liao; Weijun Xu; Julie R. Jones; David B. Everman; Heather Flanagan-Steet; Thomas H. Keller; David M. Virshup ABSTRACT Wnt signaling is essential for normal development and is a therapeutic target in cancer. The enzyme PORCN, or porcupine, is a membrane-bound O -acyltransferase...

... of PGCs greatly limits their application. Studies have shown that the formation of mammalian PGCs is induced by BMP4 signal, but the mechanism underlying chicken PGC formation has not been determined. Here, we confirmed that Wnt signaling activated via BMP4 activates transcription of Lin28A by inducing β...

.... 24 1 2020 4 6 2020 © 2020. Published by The Company of Biologists Ltd 2020 http://www.biologists.com/user-licence-1-1/ Highlighted Article: The exocytic function of clathrin controls the abundance of the Wnt signaling component β-catenin through LRP5/6 and cadherin...

... by its ATPase activity and also by CK1 peptides. CK1 biosensor Protein Ser/Thr kinase RNA helicase DDX3 Activating kinase subunit Medulloblastoma Wnt signaling European Molecular Biology Organization 10.13039/100004410 Schweizerischer Nationalfonds zur Förderung der...

... in colon cancer, it was later shown to regulate planar cell polarity (PCP) and directional cell movement. PTK7 is a Wnt co-receptor; however, its role in Wnt signaling remains controversial. Here, we find evidence that places PTK7 at the intersection of canonical and non-canonical Wnt signaling pathways...

...-canonical’ due to their limited ability to activate β-catenin when expressed alone, unexpectedly, we find that multiple Wnt combinations can synergistically activate β-catenin signaling in multiple cell types. WNT1- and WNT7B-mediated synergistic Wnt signaling requires FZD5, FZD8 and LRP6, as well...

.... ( 2009 ). Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways . J. Cell Biol.   184 , 83 - 99 . 10.1083/jcb.200806049 Dejana , E. ( 2010 ). The role of wnt signaling in physiological and pathological angiogenesis . Circ. Res.   107...

...Cara Jamieson; Christina Lui; Mariana G. Brocardo; Estefania Martino-Echarri; Beric R. Henderson ABSTRACT β-Catenin transduces the Wnt signaling pathway and its nuclear accumulation leads to gene transactivation and cancer. Rac1 GTPase is known to stimulate β-catenin-dependent transcription of Wnt...

... elevated LRP6 protein levels and activated Wnt/β-catenin signaling, whereas overexpression of Vldlr suppressed Wnt signaling. Moreover, we demonstrate that the VLDLR ectodomain is essential and sufficient for inhibition of Wnt signaling. The VLDLR ectodomain accelerated internalization and degradation...

... ). Proximal events in Wnt signal transduction.   Nat. Rev. Mol. Cell Biol.   10 , 468 – 477 . Axelrod   J. D. , Miller   J. R. , Shulman   J. M. , Moon   R. T. , Perrimon   N. ( 1998 ). Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity...

... a novel function of Bmal1 in controlling myogenic differentiation through direct transcriptional activation of components of the canonical Wnt signaling cascade, a major inductive signal for embryonic and postnatal muscle growth. Genetic loss of Bmal1 in mice leads to reduced total muscle mass and Bmal1...

... showed that norrin is a vertebrate ortholog for insect burs and pburs and stimulates Wnt signaling mediated by LGR4, but not by LGR5 and 6, in mammalian cells. Although norrin could only activate LGR4, binding studies suggested interactions between norrin and LGR4, 5 and 6. Norrin, the Norrie disease...

... gene, a key regulator of the N- glycosylation pathway. DPAGT1 is a target of the canonical Wnt signaling pathway, with both β- and γ-catenins binding to Tcf at its promoter. We now report that DPAGT1 senses cell density through canonical Wnt signaling. In dense cells, depletion of β-catenin from...

...Gabriela Valls; Montserrat Codina; Rachel K. Miller; Beatriz Del Valle-Pérez; Meritxell Vinyoles; Carme Caelles; Pierre D. McCrea; Antonio García de Herreros; Mireia Duñach Summary A role for Rac1 GTPase in canonical Wnt signaling has recently been demonstrated, showing that it is required for β...

... suggested that other growth factors have important roles in controlling SSC fate. Because β-catenin-dependent Wnt signaling promotes self-renewal of various stem cell types, we hypothesized that this pathway contributes to SSC maintenance. Using transgenic reporter mice for β-catenin-dependent signaling, we...

... and is activated by growth factors . Mol. Cell. Biol. 15 , 4553 - 4561 . Kim W. , Park J. I. , Spring C. M. , Sater A. K. , Ji H. , Otchere A. A. , Daniel J. M. , McCrea P. D. ( 2004 ). Non-canonical Wnt signals are modulated by the Kaiso transcriptional...

...Ryohei Katayama; Toshiyasu Ishioka; Shinji Takada; Ritsuko Takada; Naoya Fujita; Takashi Tsuruo; Mikihiko Naito Cellular FLIP (cFLIP) inhibits the apoptosis signaling initiated by death receptor ligation. We previously reported that a long form of cFLIP (cFLIP-L) enhances Wnt signaling via...

... 5 2009 © The Company of Biologists Limited 2009 2009 Asymmetric cell division Seam cells Male tail Wnt signaling RUNX signaling mab-5 Asymmetric cell divisions produce daughter cells with distinct developmental fates, therefore representing a key mechanism of tissue...

...Jolita Hendriksen; Marnix Jansen; Carolyn M. Brown; Hella van der Velde; Marco van Ham; Niels Galjart; G. Johan Offerhaus; Francois Fagotto; Maarten Fornerod The standard model of Wnt signaling specifies that after receipt of a Wnt ligand at the membranous receptor complex, downstream mediators...