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Keywords: Wilms’ tumor
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Journal Articles
J Cell Sci (1994) 1994 (Supplement_18): 7–12.
Published: 1 January 1994
...Andrew P. Feinberg SUMMARY Wilmstumor has served as an example of Knudson’s two-hit hypothesis of recessive tumor genes, but the genetics has proven to be surprisingly complex. WT1, a tumor suppressor gene on 11p13, is mutated in only a small fraction of Wilmstumors, and a second chromosomal...