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Keywords: Weibel-Palade bodies
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Journal Articles
J Cell Sci (2020) 133 (14): jcs247312.
Published: 24 July 2020
...Francesca Patella; Daniel F. Cutler ABSTRACT The haemostatic protein von Willebrand factor (VWF) exists in plasma and subendothelial pools. The plasma pools are secreted from endothelial storage granules, WeibelPalade bodies (WPBs), by basal secretion with a contribution from agonist-stimulated...
Includes: Supplementary data
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J Cell Sci (2017) 130 (15): 2591–2605.
Published: 01 August 2017
...Nicola L. Stevenson; Ian J. White; Jessica J. McCormack; Christopher Robinson; Daniel F. Cutler; Thomas D. Nightingale ABSTRACT Weibel-Palade bodies (WPBs), the storage organelles of endothelial cells, are essential to normal haemostatic and inflammatory responses. Their major constituent protein...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (23): 5490–5499.
Published: 01 December 2013
...Emma A. Cookson; Ianina L. Conte; John Dempster; Matthew J. Hannah; Tom Carter Summary Regulated secretion from endothelial cells is mediated by WeibelPalade body (WPB) exocytosis. Plasma membrane cholesterol is implicated in regulating secretory granule exocytosis and fusion pore dynamics...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (20): 4780–4790.
Published: 15 October 2012
...Sofia Zografou; Dimitris Basagiannis; Alexandra Papafotika; Ryutaro Shirakawa; Hisanori Horiuchi; Daniel Auerbach; Mitsunori Fukuda; Savvas Christoforidis Summary WeibelPalade bodies (WPBs) are endothelial-cell-specific organelles that, upon fusion with the plasma membrane, release cargo molecules...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (17): 2964–2975.
Published: 01 September 2010
... proteins following their entry and storage into post-Golgi-regulated secretory organelles. * Authors for correspondence ( nkiskin@nimr.mrc.ac.uk ; tcarter@nimr.mrc.ac.uk ) 24 5 2010 © 2010. 2010 FRAP WeibelPalade bodies Endothelial cells Von Willebrand factor EGFP Eotaxin-3...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (1): 19–27.
Published: 01 January 2008
...Daniel J. Metcalf; Thomas D. Nightingale; Helen L. Zenner; Winnie W. Lui-Roberts; Daniel F. Cutler Weibel-Palade bodies (WPBs) are secretory organelles used for post-synthesis storage in endothelial cells that can, very rapidly, be triggered to release their contents. They carry a variety of...
Journal Articles
J Cell Sci (2007) 120 (12): 2117–2125.
Published: 15 June 2007
...Helen L. Zenner; Lucy M. Collinson; Grégoire Michaux; Daniel F. Cutler The Weibel-Palade bodies (WPBs) of endothelial cells play an important role in haemostasis and the initiation of inflammation, yet their biogenesis is poorly understood. Tubulation of their major content protein, von Willebrand...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2003) 116 (19): 3927–3938.
Published: 01 October 2003
... Fluorescence (TIRF) microscopy to visualize the three-dimensional motions of secretory organelles near the plasma membrane in living endothelial cells. Weibel-Palade bodies (WPb), the large tubular storage organelles for von Willebrand factor, were labelled with Rab27a-GFP. By contrast, green fluorescent...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2003) 116 (19): 3939–3948.
Published: 01 October 2003
... of proteins likely to be central to organelle identity is the Rab family of small GTPases. We have thus investigated Rab recruitment to membranes using endothelial cells as a model system. We report that Weibel-Palade bodies, the Von Willebrand Factor storage compartment of human umbilical vein...