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Keywords: WT1
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Journal Articles
J Cell Sci (1994) 1994 (Supplement_18): 1–5.
Published: 1 January 1994
...Kiyoshi Miyagawa; Jill Kent; Andreas Schedl; Veronica van Heyningen; Nicholas D. Hastie SUMMARY Wilms’ tumour is a paediatric kidney malignancy that arises through aberrant differentiation of nephric stem cells. We are studying the role of one Wilms’ tumour pre-disposition gene, WT1...
Journal Articles
J Cell Sci (1994) 1994 (Supplement_18): 7–12.
Published: 1 January 1994
...Andrew P. Feinberg SUMMARY Wilms’ tumor has served as an example of Knudson’s two-hit hypothesis of recessive tumor genes, but the genetics has proven to be surprisingly complex. WT1, a tumor suppressor gene on 11p13, is mutated in only a small fraction of Wilms’ tumors, and a second chromosomal...