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Keywords: WAVE
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Journal Articles
J Cell Sci (2021) 134 (23): jcs258891.
Published: 09 December 2021
...Alexander Hirschhäuser; Marianne van Cann; Sven Bogdan ABSTRACT The WAVE regulatory complex (WRC) is the main activator of the Arp2/3 complex, promoting lamellipodial protrusions in migrating cells. The WRC is basally inactive but can be activated by Rac1 and phospholipids, and through...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (14): 2235–2241.
Published: 15 July 2017
... of the actin regulatory WAVE complex . Nature   468 , 533 - 538 . 10.1038/nature09623 Chen , B. , Brinkmann , K. , Chen , Z. , Pak , C. W. , Liao , Y. , Shi , S. , Henry , L. , Grishin , N. V. , Bogdan , S. and Rosen , M. K. ( 2014 ). The WAVE regulatory...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (20): 3756–3769.
Published: 15 October 2016
... and actin polymerization is fundamental in cell migration, but a dynamic view of the underlying molecular mechanisms is still missing. The Rac1 GTPase controls actin polymerization at protrusions by interacting with its effector, the Wave regulatory complex (WRC). The exocyst complex, which functions...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (18): 3426–3436.
Published: 15 September 2016
.... Severe defects in myoblast fusion are caused by the loss of Kette (a homolog of Nap1 and Hem-2, also known as NCKAP1 and NCKAP1L, respectively), a member of the regulatory complex formed by Scar or WAVE proteins (represented by the single protein, Scar, in flies). kette mutants form finger-like...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (13): 2493–2499.
Published: 01 July 2016
...Ripla Arora; Emilie Abby; Adam D. J. Ross; Andrea V. Cantu; Michael D. Kissner; Vianca Castro; Hsin-Yi Henry Ho; Gabriel Livera; Diana J. Laird ABSTRACT Mouse ovarian germ cells enter meiosis in a wave that propagates from anterior to posterior, but little is known about contribution of germ cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (3): 604–620.
Published: 01 February 2016
... as WAVE), WASP and WASH (also known as CG13176), have been analyzed so far. Here, we characterized WHAMY, the fourth Drosophila WASP family member. whamy originated from a wasp gene duplication and underwent a sub-neofunctionalization. Unlike WASP, we found that WHAMY specifically interacted...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (5): 723–730.
Published: 01 March 2007
... cells Lymphocyte WASp WAVE HS1 Cofilin Ezrin Moesin Immune synapse Distal pole complex Upon encountering an antigen-presenting cell (APC), a T cell undergoes dramatic structural changes. Migration ceases, the uropod retracts, and the leading edge flattens against the surface of the APC...
Journal Articles
J Cell Sci (2007) 120 (1): 86–100.
Published: 01 January 2007
..., the precise molecular mechanisms that underlie cell-cell adhesion formation remain unclear. Here we show that Wiskott-Aldrich syndrome protein family verprolin-homologous protein (WAVE)-mediated reorganization of actin, downstream of Rac plays an important role in normal development of cadherin-dependent cell...
Includes: Supplementary data
Journal Articles
J Cell Sci (2003) 116 (12): 2577–2583.
Published: 15 June 2003
... and Cdc42. The localisation of EGFP-IRSp53 in living cells was consistent with the immunofluorescence localisation of myc-IRSp53. * Author for correspondence (e-mail: jvsmall@imolbio.oeaw.ac.at ) 7 3 2003 © The Company of Biologists Limited 2003 2003 IRSp53 WAVE Mena...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2003) 116 (2): 239–246.
Published: 15 January 2003
... the driving force behind the formation and elongation. We tried to clarify how signals in response to extracellular cues are transformed to induce filopodial generation and extension. Observations on the formation process of filopodia at growth cones in the neuroblastoma cell line NG108 showed that WAVE (WASP...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2001) 114 (24): 4533–4542.
Published: 15 December 2001
... verprolin-homologous protein (WAVE) 2 than when activated by the VCA domain alone. By contrast, there was no difference between wild-type N-WASP or WAVE2 and VCA in the branching efficiency on de novo filaments, which are thought to consist mainly of ADP-phosphate filaments. This increased branching...