... regulates endocytosis in fission yeast via its association with the myosin-I tail, thereby limiting association of the yeast WASp with myosin-1 at the base of endocytic invaginations. Bbc1 NPF WASp Actin Endocytosis Verprolin National Institute of General Medical Sciences 10.13039...

... counterbalanced by Arp2/3-dependent actin polymerization, generates continuous actin network turnover in a biomimetic minimal cortex. WASP Cytoskeletal dynamics In vitro reconstitution Supported lipid bilayer Synthetic biology Bundesministerium für Bildung und Forschung 10.13039/501100002347...

...Olga Alekhina; Ezra Burstein; Daniel D. Billadeau ABSTRACT Proteins of the Wiskott–Aldrich syndrome protein (WASP) family function as nucleation-promoting factors for the ubiquitously expressed Arp2/3 complex, which drives the generation of branched actin filaments. Arp2/3-generated actin regulates...

... Secretion Branched actin Salivary gland Myosin Drosophila WASp Arp2 Arp3 4D imaging National Institute of Dental and Craniofacial Research 10.13039/100000072 Z01-DE-000713 Exocytosis is the process in which cargo that has been synthesized by specialized cells is delivered...

...Klaus Brinkmann; Moritz Winterhoff; Susanne-Filiz Önel; Jörg Schultz; Jan Faix; Sven Bogdan ABSTRACT Wiskott–Aldrich syndrome proteins (WASPs) are nucleation-promoting factors (NPF) that differentially control the Arp2/3 complex. In Drosophila , three different family members, SCAR (also known...

... regulator WASp. From in vitro cell biology experiments, and biochemical and structural approaches, we know much about the functional domains of WASp and how WASp might regulate the dynamic actin cytoskeleton downstream of activators such as Cdc42, but in vivo experiments are much more challenging...

...Athanassios Dovas; Jean-Claude Gevrey; Alberto Grossi; Haein Park; Wassim Abou-Kheir; Dianne Cox Podosomes, adhesion structures capable of matrix degradation, have been linked with the ability of cells to perform chemotaxis and invade tissues. Wiskott-Aldrich Syndrome protein (WASp), an effector...

...Ana Cvejic; Chris Hall; Magdalena Bak-Maier; Maria Vega Flores; Phil Crosier; Michael J. Redd; Paul Martin Wiskott-Aldrich syndrome protein (WASp) is haematopoietically restricted, and is the causative protein underlying a severe human disorder that can lead to death due to immunodeficiency...

... of the relevant actin-regulatory proteins, and significant progress has been made in our understanding of how these proteins choreograph molecular movements associated with T-cell activation. Proteins such as WASp, WAVE2, HS1 and cofilin direct the formation of a cortical actin scaffold at the immune synapse...

..., North Chicago, IL 60064, USA ‡ Present address: Laboratory of Chromosome and Cell Biology, The Rockefeller University, New York, NY 10021, USA 4 1 2006 © The Company of Biologists Limited 2006 2006 Microtubule WASP Neuron Nucleus Hearing RS domain...

...Assel Biyasheva; Tatyana Svitkina; Patricia Kunda; Buzz Baum; Gary Borisy The protrusion of two distinct actin-containing organelles, lamellipodia and filopodia, is thought to be regulated by two parallel pathways: from Rac1 through Scar/WAVEs to lamellipodia, and from Cdc42 through N-WASP...

... the driving force behind the formation and elongation. We tried to clarify how signals in response to extracellular cues are transformed to induce filopodial generation and extension. Observations on the formation process of filopodia at growth cones in the neuroblastoma cell line NG108 showed that WAVE (WASP...

...Tadaomi Takenawa; Hiroaki Miki ABSTRACT Reorganization of cortical actin filaments plays critical roles in cell movement and pattern formation. Recently, the WASP and WAVE family proteins WASP and N-WASP, and WAVE1, WAVE2 and WAVE3 have been shown to regulate cortical actin filament reorganization...

... and functional regards. Formation of podosomes has been shown to be dependent on the small GTPase CDC42Hs and its effector Wiskott-Aldrich syndrome protein (WASp). In this study, we investigated the functional relation between podosomes and the microtubule system in primary human macrophages. We demonstrate...

... 2000 Actin nucleation Scar WASP ActA Listeria monocytogenes Listeria monocytogenes is a gram positive facultative intracellular pathogen for humans and animals with a significant mortality rate in unborn children and elderly or immunocompromised individuals ( Gellin and Broome...