...Arunas Kvainickas; Ana Jimenez Orgaz; Heike Nägele; Britta Diedrich; Kate J. Heesom; Jörn Dengjel; Peter J. Cullen; Florian Steinberg ABSTRACT Retromer and the associated actin-polymerizing WASH complex are essential for the endocytic recycling of a wide range of integral membrane proteins...

...Zhi-Hui Deng; Timothy S. Gomez; Douglas G. Osborne; Christine A. Phillips-Krawczak; Jin-San Zhang; Daniel D. Billadeau ABSTRACT The pentameric WASH complex is best known for its role in regulating receptor trafficking from retromer-rich endosomal subdomains. FAM21 functions to stabilize the WASH...

..., a key component of which is SNX1. Cargo selection is mediated by the VPS35–VPS29–VPS26 trimer, which additionally recruits the WASH complex through VPS35 binding to the WASH complex subunit FAM21. Loss of function of the WASH complex leads to dysregulation of endosome tubulation, although it is unclear...

... receptors in the trans-Golgi network. Recent progress in studies of retromer have identified new retromer-interacting proteins, including the WASH complex and cargo such as the Wntless/MIG-14 protein, which now extends the role of retromer beyond the endosome-to-Golgi pathway and has revealed that retromer...