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Keywords: Vinculin
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Journal Articles
J Cell Sci (2023) 136 (12): jcs260104.
Published: 14 June 2023
...Gillian DeWane; Nicholas M. Cronin; Logan W. Dawson; Christy Heidema; Kris A. DeMali ABSTRACT Vinculin is an actin-binding protein present at cell–matrix and cell–cell adhesions, which plays a critical role in bearing force experienced by cells and dissipating it onto the cytoskeleton. Recently, we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2023) 136 (8): jcs260576.
Published: 20 April 2023
... in linking mechanical coupling to the actin cytoskeleton and adhesion signaling. Adhesion Signaling Kindlin Rap1 Paxillin RIAM PIP2 Vinculin Actin American Society of Hematology http://dx.doi.org/10.13039/100001422 Pennsylvania Department of Health http://dx.doi.org...
Journal Articles
J Cell Sci (2020) 133 (8): jcs238964.
Published: 28 April 2020
... profiles. Podosomes Invadopodia Actin Myosin Vinculin LSP1 Macro Fiji Podosomes are micron-sized, actin-based adhesion and invasion structures. Together with invadopodia of cancer cells, they form the subgroup of invadosome adhesions ( Linder et al., 2011 ; Murphy and Courtneidge...
Includes: Supplementary data
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Mechanobiology
J Cell Sci (2018) 131 (24): jcs216648.
Published: 14 December 2018
... by dephosphorylating vinculin Y822. To specifically probe a role for SHP-2 in E-cadherin mechanotransduction, we mutated vinculin so that it retains its phosphorylation but cannot be dephosphorylated. Cells expressing the mutant vinculin have increased contractility. This work provides a mechanism for inactivating E...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2018) 131 (6): jcs206656.
Published: 20 March 2018
...Poonam Sehgal; Xinyu Kong; Jun Wu; Raimon Sunyer; Xavier Trepat; Deborah Leckband ABSTRACT This study reports novel findings that link E-cadherin (also known as CDH1)-mediated force-transduction signaling to vinculin targeting to intercellular junctions via epidermal growth factor receptor (EGFR...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2017) 130 (14): 2277–2291.
Published: 15 July 2017
... Rac1 activation associated with dramatic actin cytoskeleton rearrangements. Our study demonstrates that the mechanosensitive focal adhesion (FA) protein vinculin, and both focal adhesion kinase (FAK, also known as PTK2) and Rab5 (both the Rab5a and Rab5b isoforms) have key roles in regulating...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2017) 130 (9): 1612–1624.
Published: 1 May 2017
... (FLAP) experiments, we found that the mobility of core FA proteins correlates with their function. Structural proteins such as tensin, talin and vinculin are significantly less mobile in FAs than signaling proteins such as FAK (also known as PTK2) and paxillin. The mobilities of the structural proteins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (1): 152–163.
Published: 1 January 2017
... polymerization and retrograde flow of actin, which stabilizes integrins and recruits vinculin to preformed adhesions, particularly those near the leading edge of invasive cells. Rap1 activity also contributes to the tension-induced collective invasive elongation of tumor cell clusters and it enhances tumor cell...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2016) 129 (24): 4496–4508.
Published: 15 December 2016
... between α-Catenin and Vinculin, and a tension-dependent recruitment of Vinculin to amniosersoa apical cell membranes, suggesting the existence of a mechano-sensitive module operating in this tissue. References Benjamin , J. M. , Kwiatkowski , A. V. , Yang , C. , Korobova , F...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Adhesion
J Cell Sci (2016) 129 (12): 2416–2429.
Published: 15 June 2016
..., that phosphorylation of cortactin decreases its interaction with β-catenin and the actin-binding protein vinculin. In addition, binding of vinculin to β-catenin, as well as linkage of vinculin to F-actin, are also significantly compromised upon phosphorylation of cortactin. Accordingly, we found that regulation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (18): 3435–3443.
Published: 15 September 2015
...Vera Auernheimer; Lena A. Lautscham; Maria Leidenberger; Oliver Friedrich; Barbara Kappes; Ben Fabry; Wolfgang H. Goldmann ABSTRACT The focal adhesion protein vinculin connects the actin cytoskeleton, through talin and integrins, with the extracellular matrix. Vinculin consists of a globular head...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (7): 1341–1351.
Published: 1 April 2015
... cytoskeleton, Rho-associated protein kinase 1 (ROCK1) and phosphoinositide 3-kinase. VE-cadherin-mediated mechanotransduction triggered local actin and vinculin recruitment, as well as global signals that altered focal adhesions and disrupted peripheral intercellular junctions. Confocal imaging revealed...
Includes: Supplementary data
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Journal Articles
Journal Articles
J Cell Sci (2013) 126 (2): 403–413.
Published: 15 January 2013
... events that might occur within a key mechanosensitive system at cell–cell junctions; the cadherin–F-actin interface, at which α-catenin and vinculin form a central module. Mechanotransduction at cell–cell junctions emerges as an important signaling mechanism, and we present examples of its potential...
Journal Articles
Journal Articles
J Cell Sci (2010) 123 (4): 567–577.
Published: 15 February 2010
...Xiao Peng; Laura E. Cuff; Cort D. Lawton; Kris A. DeMali Vinculin was identified as a component of adherens junctions 30 years ago, yet its function there remains elusive. Deletion studies are consistent with the idea that vinculin is important for the organization of cell-cell junctions. However...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (1): 29–39.
Published: 1 January 2010
... from 0 to 500 kPa. The sequential relationship between Rac1, vinculin adhesion assembly, and replication becomes efficient at above 200 kPa because activation of Rac1 leads to vinculin assembly, actin fiber formation and, subsequently, to initiation of replication. An optimal window of elasticity (200...
Includes: Supplementary data