.... , Haskard , D. O. , Mason , J. C. , Turowski , P. and Randi , A. M. ( 2014 ). ICAM-2 regulates vascular permeability and N-cadherin localization through ezrin-radixin-moesin (ERM) proteins and Rac-1 signalling . Cell Commun. Signal.   12 , 12 . 10.1186/1478-811X-12-12...

... examined vascular permeability in EC-specific Rap1A- and Rap1B-knockout mice, cell–cell junction remodeling and EC monolayer resistivity in Rap1-deficient ECs under basal, inflammatory or elevated VEGF conditions. Deletion of either Rap1 isoform impaired de novo adherens junction (AJ) formation...

... in endothelium-restricted conditional plectin-knockout mice revealed significant distortions of AJs in stress-prone aortic arch regions and increased pulmonary vascular leakage. Our study opens a new perspective on cytoskeleton-controlled vascular permeability, where a plectin-organized vimentin scaffold keeps...

... for maintaining the integrity of endothelial cell junctions. * Author for correspondence ( peter.newman@bcw.edu ) 7 1 2011 © 2011. 2011 PECAM-1 CD31 Vascular permeability Adhesion molecules Platelet endothelial cell adhesion molecule (PECAM)-1 (CD31) is a 130 kDa type I...

... deciphered the roles of CEACAM1 in normal and pathological vascularization. We have found that Ceacam1 −/− mice exhibit a significant increase in basal vascular permeability related to increased basal Akt and endothelial nitric oxide synthase (eNOS) activation in primary murine lung endothelial cells (MLECs...

...Nikolaos A. Tountas; David L. Brautigan Cell migration and retraction are interrelated activities that are crucial for a range of physiological processes such as wound healing and vascular permeability. Immunostaining of brain sections for the specific inhibitor of type-1 protein Ser/Thr...

... endothelial barrier function, whereas Cdc42 does not affect barrier function. * Author for correspondence (e-mail: anne@ludwig.ucl.ac.uk ) 11 04 2001 © 2001 by Company of Biologists 2001 Vascular permeability Rho GTPase Actin cytoskeleton Tight junction Members of the Rho...

... junctional molecule Cell adhesion Vascular permeability The endothelium is extremely important in the regulation of immune responses: both innate immunity and adaptive immune responses depend upon the exit of white blood cells (leukocytes) from the blood and their migration across the endothelium...

... cells, protecting against hydrogen peroxide and vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) induced increases in permeability with an ED 50 of 0.2-0.5 ng/ml. These newfound abilities of KGF to induce angiogenesis and to stabilize endothelial barriers suggest...