... results in a significant decrease in the expression of the Atp6v1e2 gene and in a reduced protein abundance of the E2 subunit of vacuolar ATPase. This in turn might block the assembly of the V-ATPase subunits V 1 and V o and therefore hamper the acidification of lysosomes. Consequently, this mechanism...

... of a functional v1 component of the vacuolar ATPase.   J. Biol. Chem.   278 , 28872 – 28881 . 10.1074/jbc.M300943200 Clare   D. K. , Orlova   E. V. , Finbow   M. A. , Harrison   M. A. , Findlay   J. B. C. , Saibil   H. R. ( 2006 ). An expanded and flexible form of the vacuolar ATPase...

..., they control late endocytic traffic, phagosome and autophagosome maturation and are responsible for signaling receptor degradation. We have identified, using different approaches, the V1G1 (officially known as ATP6V1G1) subunit of the vacuolar ATPase (V-ATPase) as a RILP-interacting protein. V1G1...

... 1996 © 1996 by Company of Biologists 1996 Vacuolar ATPase Dictyostelium Concanamycin A Endo-lysosome Contractile vacuole In eukaryotic cells, many organelles including the Golgi complex, endosomes and lysosomes, are acidified (reviewed by Mellman et al., 1986 ). Many...

... ATPase over time resulted in loss of vacuolar ATPase activity and vacuolar acidification. A kinetic delay in processing of carboxypeptidase Y occurred concomitant with these physiological changes while transport of alkaline phosphatase remained unaffected. Carboxypeptidase S, another vacuolar hydrolase...

... as a starting point for generation of null alleles. * Author for correspondence 11 01 1994 05 04 1994 © 1994 by Company of Biologists 1994 ductin 16 kDa proteolipid Drosophila Manduca Vha16 gap junction vacuolar ATPase The vacuolar H + -ATPase (V-ATPase...