...William R. Critchley; Gina A. Smith; Ian C. Zachary; Michael A. Harrison; Sreenivasan Ponnambalam ABSTRACT Vascular endothelial growth factor receptor 2 (VEGFR2, encoded by KDR ) regulates endothelial function and angiogenesis. VEGFR2 undergoes ubiquitination that programs this receptor...

... cells (GECs) in a dose-dependent manner and inhibits the angiogenesis of GECs. p53 and RNA-binding motif protein 4 (RBM4) were expressed at low levels in GECs, while MDM2 and vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR) were highly expressed. In vitro and in vivo experiments...

...Oisun Jung; DeannaLee M. Beauvais; Kristin M. Adams; Alan C. Rapraeger ABSTRACT When targeted by the tumor-promoting enzyme heparanase, cleaved and shed syndecan-1 (Sdc1) then couples VEGFR2 (also known as KDR) to VLA-4, activating VEGFR2 and the directed migration of myeloma cells. But how VEGFR2...

...Ming-Shih Hwang; Michael G. Strainic; Elliot Pohlmann; Haesuk Kim; Elzbieta Pluskota; Diana L. Ramirez-Bergeron; Edward F. Plow; M. Edward Medof ABSTRACT Purified vascular endothelial cell (EC) growth factor receptor-2 (VEGFR2) auto-phosphorylates upon VEGF-A occupation in vitro , arguing...

...Dimitris Basagiannis; Sofia Zografou; Carol Murphy; Theodore Fotsis; Lucia Morbidelli; Marina Ziche; Christopher Bleck; Jason Mercer; Savvas Christoforidis ABSTRACT Endocytosis plays a crucial role in receptor signalling. VEGFR2 (also known as KDR) and its ligand VEGFA are fundamental...

...Kaori H. Yamada; Yuki Nakajima; Melissa Geyer; Kishore K. Wary; Masuko Ushio-Fukai; Yulia Komarova; Asrar B. Malik ABSTRACT Although the trafficking of newly synthesized VEGFR2 to the plasma membrane is a key determinant of angiogenesis, the molecular mechanisms of Golgi to plasma membrane...

... and increases VEGF expression, which is mediated by the induction of Krüppel-like factor 2 (KLF2). Additionally, shear stress stimulates the expression of VEGF receptor 2 (VEGFR2) and is associated with its activation. Knockdown of VEGF in shear stressed HUVECs blocks the protective effect of shear stress...

...-phosphorylated upon VEGF treatment in a SHP-1- and Src-dependent manner, and that the key residues of the long cytoplasmic domain of CEACAM1 are crucial for CEACAM1 phosphorylation and NO production. This data represents the first report, to our knowledge, of a functional link between CEACAM1 and the VEGFR2/Akt...

... MESECs, and in vivo angiogenesis. Using in vitro systems, we showed that ALK-1 is necessary and sufficient for the BMP-9-induced proliferation of MESECs, and that BMP-9 induces the expression of various targets, including VEGFR2 and Tie2, involved in the proliferation of endothelial cells. We...

...Hitoshi Sase; Tetsuro Watabe; Kyoko Kawasaki; Kohei Miyazono; Keiji Miyazawa Vascular endothelial growth factor receptor 2 (VEGFR2) plays crucial roles in vasculogenesis, a process involving cell proliferation, migration and differentiation. However, the molecular mechanism by which VEGFR2...

... prevent excessive and harmful angiogenesis are not well understood. Here, our objective was to study whether T-cell protein tyrosine phosphatase (TCPTP, also known as PTN2), which we found to be expressed in human endothelial cells, could alter VEGF signalling by controlling phosphorylation of VEGFR2. We...