... the proangiogenic actions of vascular endothelial growth factor-A (VEGF-A, also known as vascular permeability factor). Interestingly, unlike tumor endothelial cells, normal endothelial cells exhibit very low to no expression of dopamine D2 receptors. Here, for the first time, we demonstrate that through paracrine...

... permeability, signal transduction and the role of AMP-activated protein kinase (AMPK). Following stimulation with either vascular endothelial growth factor (VEGF-A) or bradykinin (BK), AMPK was rapidly and strongly phosphorylated and acted as a key mediator of permeability downstream of Ca 2+ . Accordingly...

...Ming-Shih Hwang; Michael G. Strainic; Elliot Pohlmann; Haesuk Kim; Elzbieta Pluskota; Diana L. Ramirez-Bergeron; Edward F. Plow; M. Edward Medof ABSTRACT Purified vascular endothelial cell (EC) growth factor receptor-2 (VEGFR2) auto-phosphorylates upon VEGF-A occupation in vitro , arguing...

... podosomes that arise in response to the angiogenic factor VEGF-A. Constitutive and VEGF-A-induced podosomes share similar components but exhibit marked differences in terms of gelatinolytic activity. We also show that the extracellular matrix proteins laminin and collagen-IV are key determinants of the VEGF...

... with a poor prognosis in cancer. MT1-MMP-mediated transcriptional regulation of genes in cancer cells can contribute to tumour growth, although this is poorly understood at a mechanistic level. In this study, we investigated the mechanism by which MT1-MMP regulates the expression of VEGF-A in breast cancer...

... the gene encoding vascular endothelial growth factor A (VEGF-A) and the housekeeping gene HPRT (hypoxanthine-guanine phosphoribosyltransferase) were designed with Primer Express software (Perkin-Elmer) and synthesized by Oligos Etc. (Wilsonville, OR). The sequences were as follows: VEGF-A, forward 5...