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Keywords: VEGF
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Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2016) 129 (6): 1210–1222.
Published: 15 March 2016
... development of collaterals. Here, we report the role of AGS8 in vessel formation by endothelial cells. Knockdown of AGS8 by small interfering RNA (siRNA) inhibited vascular endothelial growth factor (VEGF)-induced tube formation, as well as VEGF-stimulated cell growth and migration. VEGF stimulated...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2014) 127 (17): 3805–3816.
Published: 1 September 2014
... of angiogenesis; however, its mechanism of action is not well understood. In the present study, we demonstrate that anastellin selectively inhibits microvessel cell signaling in response to the VEGF 165 isoform, but not VEGF 121 , by preventing the assembly of the complex containing the VEGF receptor...
Journal Articles
J Cell Sci (2014) 127 (8): 1672–1683.
Published: 15 April 2014
... during normal development and in response to tumor angiogenic factors in vivo . Paxillin produces these effects by decreasing expression of neuropilin 2 (NRP2). Moreover, soluble factors secreted by tumors that stimulate vascular ingrowth, including vascular endothelial growth factor (VEGF), also...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (24): 5541–5552.
Published: 15 December 2013
... in vascular permeability induced by inflammatory stimuli and vascular endothelial growth factor (VEGF). Nitric oxide (NO) produced by endothelial NO synthase (eNOS) is crucial for VEGF-induced changes in permeability in vivo ; however, the molecular mechanism by which endogenous NO modulates endothelial...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (6): 1317–1322.
Published: 15 March 2013
...Wen Dong; Yi Li; Xiaoguang Li; Meiru Hu; Aodengqimuge; Li Sun; Ning Guo; Shengtao Yuan; Lun Song Summary Exposure to solar ultraviolet B (UVB) radiation is known to induce several pathological reactions in the skin. In these processes, upregulation of VEGF expression has been demonstrated...
Journal Articles
Journal Articles
J Cell Sci (2012) 125 (20): 4751–4760.
Published: 15 October 2012
...Mohammed A. Abdelsaid; Azza B. El-Remessy Summary Although promising, the ability to regulate angiogenesis through delivery of VEGF remains an unrealized goal. We have shown previously that physiological levels of peroxynitrite (1 µM) are required for a VEGF-mediated angiogenic response, yet...
Journal Articles
J Cell Sci (2012) 125 (4): 831–843.
Published: 15 February 2012
...Nathaniel G. dela Paz; Tony E. Walshe; Lyndsay L. Leach; Magali Saint-Geniez; Patricia A. D'Amore Vascular endothelial growth factor (VEGF) plays a crucial role in developmental and pathological angiogenesis. Expression of VEGF in quiescent adult tissue suggests a potential role in the maintenance...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (18): 3189–3200.
Published: 15 September 2010
... of cardiovascular development and vascular integrity. We investigated vascular endothelial growth factor (VEGF)-mediated ERK5 activation in primary human dermal microvascular endothelial cells (HDMECs) undergoing proliferation on a gelatin matrix, and tubular morphogenesis within a collagen gel matrix. VEGF induced...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2008) 121 (21): 3570–3580.
Published: 1 November 2008
...Elina Mattila; Kaisa Auvinen; Marko Salmi; Johanna Ivaska Vascular endothelial growth factor (VEGF) is a major angiogenic factor that triggers formation of new vessels under physiological and pathological conditions. However, the mechanisms that limit the VEGF responses in target cells and hence...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2007) 120 (10): 1810–1817.
Published: 15 May 2007
...Markus Ramsauer; Patricia A. D'Amore We used a 3D in-vitro model of angiogenesis to investigate the effects of different growth factors on vessel formation and stabilization in vitro. Vascular endothelial growth factor (VEGF) was the only factor that induced the formation, elongation and sprouting...
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2004) 117 (3): 407–415.
Published: 22 January 2004
...Yayoi Kaneko; Kenji Kitazato; Yuji Basaki Integrin-linked kinase (ILK) is one of the signaling moieties that interact with the cytoplasmic domains of integrin β1 and β3 subunits. Integrin-mediated outside-in signals cooperate with vascular endothelial growth factor (VEGF) receptor to promote...
Journal Articles
J Cell Sci (2003) 116 (12): 2461–2470.
Published: 15 June 2003
... cell migration, vascular endothelial growth factor (VEGF) gradient-driven chemotaxis, capillary-like network formation and sprouting angiogenesis. In turn, soluble EphB4-Fc is pro-adhesive and stimulates EC migration and sprouting angiogenesis. EphrinB2-mediated repulsive signals are transduced...