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Keywords: VE-cadherin
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Journal Articles
J Cell Sci (2021) 134 (7): jcs253179.
Published: 13 April 2021
..., AMPK agonists potently induced acute retinal vascular leakage. AMPK activation led to phosphorylation of endothelial nitric oxide synthase (eNOS, also known as NOS3), which in turn increased VE-cadherin (CDH5) phosphorylation on Y685. In parallel, AMPK also mediated phosphorylation of p38 MAP kinases...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (1): 206–218.
Published: 01 January 2016
... adherens junctions is a common feature of these diseases, but the role of BMPs in this process has not been investigated. BMP signaling is initiated by binding of ligand to, and activation of, BMP type I (BMPRI) and type II (BMPRII) receptors. Internalization of VE-cadherin as well as c-Src kinase...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (16): 3041–3054.
Published: 15 August 2015
...-GTPases is spatio-temporally controlled at endothelial adherens junctions by guanine-nucleotide exchange factors (GEFs) is incompletely understood. Here, we identify a crucial role for the Rho-GEF Trio in stabilizing junctions based around vascular endothelial (VE)-cadherin (also known as CDH5). Trio...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (7): 1341–1351.
Published: 01 April 2015
...Adrienne K. Barry; Ning Wang; Deborah E. Leckband ABSTRACT In this study, we present results demonstrating that mechanotransduction by vascular endothelial cadherin (VE-cadherin, also known as CDH5) complexes in endothelial cells triggers local cytoskeletal remodeling, and also activates global...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (3): 576–588.
Published: 01 February 2015
...) of leukocytes. The LBRC contains molecules involved in TEM, such as PECAM, PVR and CD99, but not VE-cadherin. Despite its importance, how membrane proteins are included in or excluded from the LBRC is not known. Immunoelectron microscopy and biochemical approaches demonstrate that inclusion into the LBRC...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (24): 5541–5552.
Published: 15 December 2013
... junctions and VE-cadherin (also known as cadherin 5), and reduced Rho activation and stress fiber formation. In addition, NO deficiency reduced VEGF-induced VE-cadherin phosphorylation and impaired the localization, but not the activation, of c-Src to cell junctions. The physiological role of eNOS...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (17): 4137–4146.
Published: 01 September 2012
...Armelle Le Guelte; Eva-Maria Galan-Moya; Julie Dwyer; Lucas Treps; Garance Kettler; Jagoda K. Hebda; Sonia Dubois; Cedric Auffray; Herve Chneiweiss; Nicolas Bidere; Julie Gavard Summary VE-cadherin-mediated cell–cell junction weakening increases paracellular permeability in response to both...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (10): 1616–1625.
Published: 15 May 2009
... (VE-) cadherin-mediated adhesion often precedes endothelial breakdown. This study aimed to stabilize VE-cadherin transinteraction and endothelial barrier function using peptides targeting the VE-cadherin adhesive interface. After modelling the transinteracting VE-cadherin structure, an inhibiting...
Journal Articles
J Cell Sci (2008) 121 (13): 2115–2122.
Published: 01 July 2008
..., ischemia and diabetes – which leads to severe, and sometimes fatal, organ dysfunction. Endothelial permeability is regulated in part by the dynamic opening and closure of cell-cell adherens junctions (AJs). In endothelial cells, AJs are largely composed of vascular endothelial cadherin (VE-cadherin...
Journal Articles
J Cell Sci (2008) 121 (1): 29–37.
Published: 01 January 2008
... tyrosine phosphorylation of the cytoskeleton-associated protein cortactin in brain microvessel endothelial cells. J. Biol. Chem. 269 , 12536 -12540. Esser, S., Lampugnani, M. G., Corada, M., Dejana, E. and Risau, W. ( 1998 ). Vascular endothelial growth factor induces VE-cadherin tyrosine...
Includes: Supplementary data
Journal Articles
J Cell Sci (2004) 117 (15): 3129–3140.
Published: 01 July 2004
... protein p0071 is a VE-cadherin- and desmoplakin-binding protein. J. Biol. Chem. 278 , 1774 -1783. Caplen, N. J., Parrish, S., Imani, F., Fire, A. and Morgan, R. A. ( 2001 ). Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems. Proc. Natl...
Journal Articles
J Cell Sci (2003) 116 (6): 1001–1011.
Published: 15 March 2003
... application we demonstrated that the strength of adhesion of VE-cadherin-coated microspheres to the surface of cultured endothelial monolayers is significantly reduced by treatment with two well-established permeability-increasing compounds,cytochalasin D and the Ca 2+ -ionophore A23187, which shows that both...
Journal Articles
J Cell Sci (2002) 115 (9): 1837–1846.
Published: 01 May 2002
...Sandra van Wetering; Jaap D. van Buul; Safira Quik; Frederik P. J. Mul; Eloise C. Anthony; Jean-Paul ten Klooster; John G. Collard; Peter L. Hordijk The integrity of the endothelium is dependent on cell-cell adhesion, which is mediated by vascular-endothelial (VE)-cadherin. Proper VE-cadherin...