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Keywords: V-ATPase
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Series: REVIEW COMMONS TRANSFER
J Cell Sci (2024) 137 (4): jcs261917.
Published: 16 February 2024
... , where its depletion results in tissue overgrowth and loss of cell polarity. Lgl links cell polarity and tissue growth through regulation of the Notch and the Hippo signalling pathways. Lgl regulates the Notch pathway by inhibiting V-ATPase activity via Vap33. How Lgl regulates the Hippo pathway...
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Membrane trafficking
J Cell Sci (2021) 134 (20): jcs258807.
Published: 25 October 2021
... of the TGN/EE and is maintained by the vacuolar H + -ATPase (V-ATPase) with support of proton-coupled antiporters. We show here that ClCd and ClCf, two distantly related members of the Arabidopsis Cl − channel (ClC) family, colocalize in the TGN/EE, where they act redundantly, and are essential for male...
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In collection:
Membrane trafficking
J Cell Sci (2021) 134 (15): jcs258459.
Published: 3 August 2021
... synthesis or Doa4 function causes a defect in sorting of a subset of ILV cargos. We show that these cargo-sorting defects are suppressed by mutations that disrupt Vph1, a subunit of vacuolar H + -ATPase (V-ATPase) complexes that acidify late endosomes and vacuoles. We further show that Vph1 dysfunction...
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J Cell Sci (2020) 133 (5): jcs233239.
Published: 18 November 2019
... previously unrecognized regulators of immune responses, while establishing close interactions with spermatozoa. RNA sequencing V-ATPase Sperm maturation Immune regulation Male reproductive tract Post-testicular regulation Male fertility Lalor Foundation Fellowship HD040793...
Journal Articles
J Cell Sci (2017) 130 (2): 344–359.
Published: 15 January 2017
... interacts with the vacuolar (V)-ATPase subunit Vha55 that is crucial to establish and maintain lysosome acidification. As a consequence, starved flies that lack WASH function show a dramatic increase in acidic autolysosomes, causing a reduced lifespan. Thus, our data highlight a conserved role for WASH...
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Journal Articles
J Cell Sci (2009) 122 (14): 2504–2513.
Published: 15 July 2009
...Ge-Hong Sun-Wada; Hiroyuki Tabata; Nobuyuki Kawamura; Minako Aoyama; Yoh Wada The nascent phagosome progressively establishes an acidic milieu by acquiring a proton pump, the vacuolar-type ATPase (V-ATPase). However, the origin of phagosomal V-ATPase remains poorly understood. We found...
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Journal Articles
J Cell Sci (2006) 119 (12): 2542–2551.
Published: 15 June 2006
...J. Du; L. Kean; A. K. Allan; T. D. Southall; S. A. Davies; C. J. McInerny; J. A. T. Dow V-ATPases play multiple roles in eukaryotes: in Drosophila , null mutations are recessive lethal. Here, mutations underlying five extant lethal alleles of vha55 , encoding the B subunit, were identified...
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J Cell Sci (2005) 118 (13): 2813–2825.
Published: 1 July 2005
...Thomas Wassmer; Marine Froissard; Helmut Plattner; Roland Kissmehl; Jean Cohen The vacuolar proton-ATPase (V-ATPase) is a multisubunit enzyme complex that is able to transfer protons over membranes against an electrochemical potential under ATP hydrolysis. The enzyme consists of two subcomplexes: V...
Journal Articles
J Cell Sci (2004) 117 (6): 827–836.
Published: 22 February 2004
... of trafficking. Moreover, we analyse the effect of the V-ATPase inhibitor bafilomycin A1 on endocytic uptake, which gives insight into the pH-dependent regulation of membrane trafficking and resorption in osteoclasts. The number of osteoclasts with dextran endocytosis was counted after fixation...
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Journal Articles
J Cell Sci (2002) 115 (14): 2893–2905.
Published: 15 July 2002
...Margaret Clarke; Jana Köhler; Quyen Arana; Tongyao Liu; John Heuser; Günther Gerisch The vacuolar H + -ATPase (V-ATPase) is a multi-subunit enzyme that plays important roles in eukaryotic cells. In Dictyostelium , it is found primarily in membranes of the contractile vacuole complex, where...
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Journal Articles
J Cell Sci (2000) 113 (9): 1577–1587.
Published: 1 May 2000
... PI-3 kinase V-ATPase Osteoclasts are terminally differentiated multinucleated cells specialized for bone matrix degradation. These highly motile cells form a tight attachment to the mineralized bone matrix, the so-called sealing zone, upon an as yet unidentified signal. Formation...
Journal Articles
J Cell Sci (1999) 112 (21): 3657–3666.
Published: 1 November 1999
...Tiina Laitala-Leinonen; Clemens Löwik; Socrates Papapoulos; H. Kalervo Väänänen ABSTRACT The role of proton transport and production in osteoclast differentiation was studied in vitro by inhibiting the transcription/translation of carbonic anhydrase II (CA II) and vacuolar H + -ATPase (V-ATPase...
Journal Articles
J Cell Sci (1996) 109 (5): 1041–1051.
Published: 1 May 1996
... 1996 V-ATPase Contractile vacuole Dictyostelium Fig. 1. Nucleotide sequence and deduced amino acid sequence of vatM cDNA. For both the nucleotide and protein sequences, the residues are numbered from the presumptive translation initiation codon. Numbers are to the left of the lines...
Journal Articles
J Cell Sci (1995) 108 (10): 3163–3170.
Published: 1 October 1995
... of the decorated tubules. In immunofluorescence studies, both polyclonal antibodies against the subunits of the V-ATPase of Dictyostelium discoideum and against the 57 kDa B-subunit of the V-ATPase of chromaffin granules gave identical labeling patterns to that produced by mAb DS-1. On cryosections, all three...
Journal Articles
J Cell Sci (1995) 108 (10): 3331–3337.
Published: 1 October 1995
..., actin, a Rab 7-like GTPase, a p34 protein corresponding to a new cysteine proteinase and the 25 kDa product of a recently sequenced D. discoideum open reading frame. * Author for correspondence 11 05 1995 13 07 1995 © 1995 by Company of Biologists 1995 V-ATPase Rab...