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Keywords: Unfolded protein response
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Journal Articles
J Cell Sci (2022) 135 (21): jcs259734.
Published: 31 October 2022
... on pharyngeal arch deficiency and found that pharyngeal arches in hspa8 mutant embryos exhibited induction of endoplasmic reticulum stress and activation of the unfolded protein response via the Perk/p-eIF2α/Atf4 signaling cascade. Inhibition of Perk/p-eIF2α/Atf4 signaling rescued the developmental deficiency...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (17): jcs258685.
Published: 6 September 2021
... of the unfolded protein response, a key parameter in Sec body formation. This work shows the role of SIKs in phase transition and re-enforces the role of IRE1 and PERK as a metabolic sensor for the level of circulating amino acids and salt. This article has an associated First Person interview with the first...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (21): jcs248526.
Published: 5 November 2020
...) family induces LD formation. Here, we establish a model system to study the role of the Saccharomyces cerevisiae FIT homologues ( ScFIT ), SCS3 and YFT2 , in the proteostasis and stress response pathways. While LD biogenesis and basal endoplasmic reticulum (ER) stress-induced unfolded protein response...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2019) 132 (5): jcs217216.
Published: 15 February 2019
...Sahana Mitra; Hyung Don Ryoo ABSTRACT Eukaryotic cells respond to an overload of unfolded proteins in the endoplasmic reticulum (ER) by activating signaling pathways that are referred to as the unfolded protein response (UPR). Much UPR research has been conducted in cultured cells that exhibit...
Journal Articles
J Cell Sci (2018) 131 (22): jcs217992.
Published: 21 November 2018
... composition. Perturbation of endoplasmic reticulum (ER) homeostasis through alteration in membrane phospholipids activates the unfolded protein response (UPR) and causes dramatic transcriptional and translational changes in the cell. To restore cellular homeostasis, the three highly conserved UPR transducers...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2017) 130 (18): 3040–3049.
Published: 15 September 2017
...Huai-Wei Huang; Xiaomei Zeng; Taiyoun Rhim; David Ron; Hyung Don Ryoo ABSTRACT IRE1 mediates the unfolded protein response (UPR) in part by regulating XBP1 mRNA splicing in response to endoplasmic reticulum (ER) stress. In cultured metazoan cells, IRE1 also exhibits XBP1-independent biochemical...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (12): 2317–2328.
Published: 15 June 2016
...Max Brown; Natalie Strudwick; Monika Suwara; Louise K. Sutcliffe; Adina D. Mihai; Ahmed A. Ali; Jamie N. Watson; Martin Schröder ABSTRACT Accumulation of unfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR). In mammalian cells, UPR signals generated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (9): 1762–1772.
Published: 1 May 2015
... the unfolded protein response (UPR). When dimerized, the core stress‐sensing region (CSSR) of Ire1 directly captures unfolded proteins and forms a high‐order oligomer, leading to clustering and activation of Ire1. The CSSR is N‐terminally flanked by an intrinsically disordered subdomain, which we previously...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (17): 3649–3658.
Published: 1 September 2014
...Davide Eletto; Eric Chevet; Yair Argon; Christian Appenzeller-Herzog ABSTRACT In many physiological contexts, intracellular reduction–oxidation (redox) conditions and the unfolded protein response (UPR) are important for the control of cell life and death decisions. UPR is triggered...
Journal Articles
J Cell Sci (2014) 127 (15): 3227–3232.
Published: 1 August 2014
... the unfolded protein response (UPR), an essential ER signaling pathway. Through molecular and genetic approaches, we show that loss of the ER-shaping GTPase Root Hair Defective 3 (RHD3) specifically disrupts the UPR by interfering with the mRNA splicing function of the master regulator IRE1. These findings...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (7): 1604–1617.
Published: 1 April 2013
... Endoplasmic reticulum Glutathione Green fluorescent protein Reduction potential Unfolded protein response The endoplasmic reticulum (ER) constitutes the starting point of the secretory pathway where secretory and membrane proteins are synthesized. Correct folding of these ER client proteins...
Includes: Supplementary data
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Journal Articles
J Cell Sci (2010) 123 (13): 2145–2154.
Published: 1 July 2010
... ). The mechanism of cystic fibrosis transmembrane conductance regulator transcriptional repression during the unfolded protein response . J. Biol. Chem. 283 , 12154 - 12165 . Bateman J. F. , Freddi S. , Nattrass G. , Savarirayan R. ( 2003 ). Tissue-specific RNA surveillance...
Journal Articles
J Cell Sci (2010) 123 (9): 1438–1448.
Published: 1 May 2010
... in the endoplasmic reticulum, and less capable of activating transcription driven by unfolded protein response element or C-reactive protein promoter. Taken together, our findings suggest that N-linked glycosylation is required for full activation of CREB-H through intramembrane proteolysis. Our work also reveals...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (5): 787–794.
Published: 1 March 2010
... capacity before client protein production prevented cellular unfolded-protein stress, confirmed by the silence of the most conserved branch of the unfolded protein response. Thyrocytes set an example of physiological adaptation of cells to a future potentially stress-causing situation, which suggests...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (21): 3942–3953.
Published: 1 November 2009
... in the endoplasmic reticulum (ER) and induction of the unfolded protein response (UPR), the molecular mechanisms that govern phenotypic heterogeneity remain poorly understood. To address this issue, we examined the cellular response to missense mutants of PLP that are associated with distinct disease phenotypes. We...
Includes: Supplementary data
Journal Articles