...Richard T. Libby; Concepcion Lillo; Junko Kitamoto; David S. Williams; Karen P. Steel Myosin Va is an actin-based motor molecule, one of a large family of unconventional myosins. In humans, mutations in MYO5A cause Griscelli syndrome type 1 and Elejalde syndrome, diseases characterized...

...Tama Hasson Actin is found at the cortex of the cell where endocytosis occurs, but does it play a role in this essential process? Recent studies on the unconventional myosin, myosin VI, an actin-based molecular motor, provide compelling evidence that this myosin and therefore actin is involved...

... 2002 Unconventional myosin Myosin VIIa MYO7A Usher syndrome Mutations in the gene encoding myosin VIIa can cause deafness and blindness, known as Usher syndrome 1B ( Weil et al., 1995 ). Myosin VIIa is found in a variety of tissues ( Hasson et al., 1995 ; Wolfrum et al., 1998 ). Most...

...Jonathan S. Berg; Bruce H. Derfler; Christopher M. Pennisi; David P. Corey; Richard E. Cheney ABSTRACT Myosin-X is the founding member of a novel class of unconventional myosins characterized by a tail domain containing multiple pleckstrin homology domains. We report here the full-length cDNA...

...Wu-Min Deng; Kevin Leaper; Mary Bownes ABSTRACT We report that Drosophila unconventional myosin VI, encoded by Myosin heavy chain at 95F ( Mhc95F ), is required for both imaginal disc and egg chamber morphogenesis. During oogenesis, Mhc95F is expressed in migrating follicle cells, including...

...J. A. Wirth; K. A. Jensen; P. L. Post; W. M. Bement; M. S. Mooseker ABSTRACT The full-length primary structure and expression profile of a novel unconventional myosin heavy chain, human myosin-IXb, is described. The primary structure of this myosin predicts a 229 kDa protein that together with its...