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Keywords: Ubiquitylation
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Journal Articles
J Cell Sci (2024) 137 (9): jcs259775.
Published: 16 May 2024
... availability and cellular stress. Damaged or superfluous peroxisomes are removed mainly by pexophagy, the selective autophagy of peroxisomes induced by ubiquitylation of peroxisomal membrane proteins or ubiquitin-independent processes. Dysregulated pexophagy impairs peroxisome homeostasis and has been linked...
Includes: Supplementary data
Journal Articles
J Cell Sci (2024) 137 (4): jcs261579.
Published: 28 February 2024
... Ciliopathy CP110 CCP110 Degradation Proteasome Ubiquitylation National Institute of General Medical Sciences http://dx.doi.org/10.13039/100000057 R35GM144102 Dutch fabric merchant and exemplary microscopy pioneer Antonie van Leeuwenhoek described microorganisms with flagella...
Journal Articles
J Cell Sci (2024) 137 (2): jcs261527.
Published: 26 January 2024
... that reversible, non-degradative ubiquitylation regulates the function of the actin polymerase VASP in developing neurons. However, the underlying mechanism of how ubiquitylation impacts VASP activity was unknown. Here, we show that mimicking multi-monoubiquitylation of VASP at K240 and K286 negatively regulates...
Includes: Supplementary data
Journal Articles
J Cell Sci (2023) 136 (23): jcs260868.
Published: 1 December 2023
.... Lem2 SUMOylation Ubiquitylation Schizosaccharomyces pombe Centromeres Wellcome Trust http://dx.doi.org/10.13039/100010269 202771/Z/16/Z Medical Research Council G1000505 Leverhulme Trust http://dx.doi.org/10.13039/501100000275 RPG-2014-050...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2022) 135 (10): jcs260059.
Published: 19 May 2022
... activity. Major facilitator superfamily MFS Transporters Monocarboxylic acids Endocytosis Arrestin Cytosolic termini Protein sorting Protein turnover Substrate specificity Ubiquitylation Fundação para a Ciência e a Tecnologia http://dx.doi.org/10.13039/501100001871 UIDB/04050...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (2): jcs259018.
Published: 17 January 2022
... phosphorylation at Ser68 and inhibited apoptosis in A549 cells. Mechanistically, CypA could mediate the phosphorylation of Twist1 at Ser68 via p38 mitogen-activated protein kinase (also known as MAPK14), which inhibited its ubiquitylation-mediated degradation. In addition, CypA increased interaction between...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2021) 134 (16): jcs257790.
Published: 18 August 2021
... implicated in the production of WNT proteins. Here, we investigated how the WNT secretory factor EVI (also known as WLS) is ubiquitylated, recognised by ERAD components and subsequently removed from the secretory pathway. We performed a focused immunoblot-based RNAi screen for factors that influence EVI/WLS...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (10): jcs257485.
Published: 24 May 2021
... a gene encoding an uncharacterized α-arrestin-like protein, Aly3/SPCC584.15c. α-arrestins are thought to recruit a ubiquitin ligase to membrane-associated proteins. Consistently, Ght5 is ubiquitylated in TORC2-deficient cells, and this ubiquitylation is dependent on Aly3. TORC2 supposedly enables cell...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (8): jcs257188.
Published: 28 April 2021
... host to viral mRNAs are poorly understood. Here, we uncover a role for the ribosome-associated quality control (RQC) factor ZNF598 during vaccinia virus mRNA translation. ZNF598 acts on collided ribosomes to ubiquitylate 40S subunit proteins uS10 (RPS20) and eS10 (RPS10), initiating RQC-dependent...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (18): jcs251314.
Published: 15 September 2020
... is ubiquitylated by the anaphase promoting complex/cyclosome (APC/C) and its cofactor Cdh1 (also known as FZR1) and is subsequently degraded in G1 phase. Cdh1 binds to regions within the N terminus of borealin that act as a non-canonical degron. Aurora B has also been shown previously to be degraded by the APC/C...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (12): jcs240093.
Published: 24 June 2020
...Marie Le Boulch; Audrey Brossard; Gaëlle Le Dez; Sébastien Léon; Gwenaël Rabut ABSTRACT Ubiquitylation is a reversible post-translational protein modification that regulates a multitude of cellular processes. Detection of ubiquitylated proteins is often challenging because of their low abundance...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (7): jcs228072.
Published: 7 April 2020
... they contribute to disease development. Ubiquitin HECT E3 ubiquitin ligase Ubiquitylation Protein-protein interactions Protein turnover Cell signaling Cancer Neurological disorders Neurodevelopmental disorders Neurodegeneration National Institutes of Health 10.13039/100000002...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
In collection:
Cilia and flagella
J Cell Sci (2018) 131 (24): jcs219527.
Published: 12 December 2018
... CEP97 CP110 Cullin-3 KCTD10 Ubiquitylation Japan Society for the Promotion of Science 10.13039/501100001691 15H04347 15H01197 18H02398 16K20910 Primary cilia are non-motile cilia protruding from the plasma membrane of the majority of vertebrate cells. They function...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (15): jcs204321.
Published: 9 August 2018
... in these processes. Using ubiquitylation-type-specific antibodies and Cx43 lysine-to-arginine mutants we show that ∼8% of a GJ, localized in central plaque domains, is K63-polyubiquitylated on K264 and K303. Levels and localization of ubiquitylation correlated well with: (1) the short turnover rate of Cxs and GJs...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (10): jcs210575.
Published: 22 May 2018
... of transcriptionally active β-catenin–TCF/Lef complexes. We now demonstrate that XIAP is phosphorylated by GSK3 at threonine 180, and that an alanine mutant (XIAP T180A ) exhibits decreased Wnt activity compared to wild-type XIAP in cultured human cells and in Xenopus embryos. Although XIAP T180A ubiquitylates TLE3...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2017) 130 (20): 3578–3587.
Published: 15 October 2017
... Ubiquitylation Proteasome Protein degradation Acetylation/deacetylation Acetyldegron Lipopolysaccharide National Institutes of Health 10.13039/100000002 HL125435 Cellular proteins are dynamic and stringently monitored in responding to endogenous and exogenous pathophysiological inputs...
Includes: Supplementary data