...://www.biologists.com/user-licence-1-1/ Summary: The endosomal recruitment of UBR4 is essential for the biogenesis of early endosomes and endosome-related processes such as the trafficking and proteolysis of endocytosed cargos. Ubiquitin-proteasome system Autophagy UBR box N-terminal arginylation...

...Abdelhalim Loukil; Manuela Zonca; Cosette Rebouissou; Véronique Baldin; Olivier Coux; Martine Biard-Piechaczyk; Jean-Marie Blanchard; Marion Peter ABSTRACT Cyclin A2 is a key player in the regulation of the cell cycle. Its degradation in mid-mitosis relies on the ubiquitin-proteasome system (UPS...

.... * Author for correspondence ( [email protected] ; [email protected] ) Competing interests The authors declare no competing interests. 16 05 2013 8 01 2014 © 2014. Published by The Company of Biologists Ltd 2014 HERP ER Stress recovery Ubiquitin–proteasome system Ube2g2...

... by facilitating cytoplasmic anchoring and degradation of p53 through a ubiquitin–proteasome system. Concomitantly, decreased levels of nuclear DGKζ engender downregulation of p53 transcriptional activity. Consistent with these in vitro cellular experiments, DGKζ-deficient brain exhibits high levels of p53 protein...

... 2010. 2010 RhoGTPase signalling Ubiquitin–Proteasome System Ubiquitylation RhoGTPases are members of the Ras GTPase superfamily and are key regulators of the cellular cytoskeleton. They control cell adhesion, migration, gene transcription and cell division ( Bosco et al., 2009...

... negative ubiqbiquitiuitin mutants, cellular fractionation and siRNA techniques, we demonstrate the involvement of the ubiquitin-proteasome system in the rapid degradation of UCP2. Importantly, we resolve the issue of whether intramitochondrial proteins can be degraded by the cytosolic proteasome...

...Paula van Tijn; Femke M. S. de Vrij; Karianne G. Schuurman; Nico P. Dantuma; David F. Fischer; Fred W. van Leeuwen; Elly M. Hol The ubiquitin-proteasome system is the main regulated intracellular proteolytic pathway. Increasing evidence implicates impairment of this system in the pathogenesis...

...Thomas Dino Rockel; Dominik Stuhlmann; Anna von Mikecz The ubiquitin proteasome system plays a fundamental role in the regulation of cellular processes by degradation of endogenous proteins. Proteasomes are localized in both, the cytoplasm and the cell nucleus, however, little is known about...