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Keywords: Ubiquitin ligase
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Proteostasis
J Cell Sci (2020) 133 (11): jcs239335.
Published: 11 June 2020
... that regulates these physiological processes. Moreover, no mutations in any of the known regulators of lysosomal exocytosis in primary tumors of patients have been characterized. Here we demonstrate that RNF167-a, a lysosomal-associated ubiquitin ligase, negatively regulates lysosomal exocytosis by inducing...
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Proteostasis
J Cell Sci (2015) 128 (22): 4220–4234.
Published: 15 November 2015
...-arrestins bind the Rho1 GTPase and regulate internalization of selective cargo through the clathrin-independent endocytic pathway. Plasma membrane Internalization Protein trafficking Ubiquitin ligase Yeast Organelle identity, membrane composition and cellular signaling rely on accurate...
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Proteostasis
J Cell Sci (2013) 126 (17): 3972–3981.
Published: 1 September 2013
... starvation conditions, is confined to the Golgi. Here, we show that the loss of either pub1 + , encoding an E3 ubiquitin ligase, or any1 + , encoding a β-arrestin-like protein, allows constitutive expression of Aat1 on the plasma membrane in Δtsc2 cells, suggesting that Pub1 and Any1 are required...
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J Cell Sci (2013) 126 (13): 2798–2809.
Published: 1 July 2013
.... The identification and characterization of a specific ubiquitin ligase for TfR is important in understanding the mechanism of iron homeostasis. Here, we show that membrane-associated RING-CH (MARCH) 8 ubiquitinates TfR and promotes its lysosomal degradation. Similar to other RING-type ubiquitin ligases, the RING-CH...
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Proteostasis
J Cell Sci (2012) 125 (7): 1727–1737.
Published: 1 April 2012
...Pascal St-Pierre; Thao Dang; Bharat Joshi; Ivan R. Nabi Gp78 (also known as AMFR and RNF45) is an E3 ubiquitin ligase that targets proteins for proteasomal degradation through endoplasmic reticulum (ER)-associated degradation (ERAD). In this study, we showed that gp78-mediated ubiquitylation...
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Proteostasis
J Cell Sci (2011) 124 (13): 2277–2286.
Published: 1 July 2011
..., is heat-shock factor 1 (HSF1) – a transcription factor that activates the transcription of heat-shock genes and confers protection against stress-induced cell death. In the present study, we investigated the role of the phosphatase laforin and the ubiquitin ligase malin in the HSF1-mediated heat-shock...
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Proteostasis
J Cell Sci (2003) 116 (4): 605–616.
Published: 15 February 2003
... importance for HBV biology remains open. The RING-H2 domain was functional in and essential for self- and trans-ubiquitylation in vitro and for proteasome-mediated turnover of the protein in vivo. We therefore termed it hRUL138 for human RNA-binding ubiquitin ligase of 138 kDa. hRUL138 mRNAs are expressed...
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Proteostasis
J Cell Sci (2002) 115 (9): 1847–1857.
Published: 1 May 2002
... the temperature sensitivity of pub1Δ cells, suggesting that the HECT domain of Pub2p has the catalytic activity of a ubiquitin ligase. We conclude that Pub2p is a HECT-type ubiquitin-protein ligase that shares partially overlapping function with Pub1p. References Alfa, C., Fantes, P., Hyams, J., McLeod, M...
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Proteostasis
J Cell Sci (1998) 111 (17): 2575–2585.
Published: 1 September 1998
... splicing and chromosome structure/function. βgeo Splicing Heterochromatin Kinase Ubiquitin ligase Determining the subcellular location of proteins is a pivotal guide to further investigations of their functions. The nucleus is compartmentalised with respect to both structure and function...