... molecules. Intramembrane proteolysis Endoplasmic reticulum-associated protein degradation ERAD Ubiquitin ligase Endoplasmic reticulum Protein quality control Signal peptide peptidase SPP Wellcome Trust http://dx.doi.org/10.13039/100010269 223153/Z/21/Z University...

... that regulates these physiological processes. Moreover, no mutations in any of the known regulators of lysosomal exocytosis in primary tumors of patients have been characterized. Here we demonstrate that RNF167-a, a lysosomal-associated ubiquitin ligase, negatively regulates lysosomal exocytosis by inducing...

... for correspondence ([email protected]) Competing interests The authors declare no competing or financial interests. 19 11 2018 3 1 2019 © 2019. Published by The Company of Biologists Ltd 2019 http://www.biologists.com/user-licence-1-1/ Summary: The ubiquitin ligase...

... endocytosis and recycling by the arrestin-related protein Rod1 and the ubiquitin ligase Rsp5 . eLife   3 , e03307 . 10.7554/eLife.03307 Becuwe , M. , Herrador , A. , Haguenauer-Tsapis , R. , Vincent , O. and Léon , S. (2012). Ubiquitin-mediated regulation of endocytosis...

... underlying epithelia. In this study, we identify RNF41, an E3 ubiquitin ligase, as a novel Par-1b (also known as MARK2) effector in the cell–ECM pathway. Par-1b binds to and phosphorylates RNF41 on serine 254. Phosphorylation of RNF41 by Par-1b is required for epithelial cells to localize laminin-111...

... starvation conditions, is confined to the Golgi. Here, we show that the loss of either pub1 + , encoding an E3 ubiquitin ligase, or any1 + , encoding a β-arrestin-like protein, allows constitutive expression of Aat1 on the plasma membrane in Δtsc2 cells, suggesting that Pub1 and Any1 are required...

...Jay Shankar; Liliana D. Kojic; Pascal St-Pierre; Peter T. C. Wang; Min Fu; Bharat Joshi; Ivan R. Nabi Summary Gp78 is a cell surface receptor that also functions as an E3 ubiquitin ligase in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. The Gp78 ligand, the glycolytic enzyme...

.... The identification and characterization of a specific ubiquitin ligase for TfR is important in understanding the mechanism of iron homeostasis. Here, we show that membrane-associated RING-CH (MARCH) 8 ubiquitinates TfR and promotes its lysosomal degradation. Similar to other RING-type ubiquitin ligases, the RING-CH...

...Pascal St-Pierre; Thao Dang; Bharat Joshi; Ivan R. Nabi Gp78 (also known as AMFR and RNF45) is an E3 ubiquitin ligase that targets proteins for proteasomal degradation through endoplasmic reticulum (ER)-associated degradation (ERAD). In this study, we showed that gp78-mediated ubiquitylation...

..., is heat-shock factor 1 (HSF1) – a transcription factor that activates the transcription of heat-shock genes and confers protection against stress-induced cell death. In the present study, we investigated the role of the phosphatase laforin and the ubiquitin ligase malin in the HSF1-mediated heat-shock...

..., the p97/CDC-48–UFD-1–NPL-4 complex interacted with the E3 ubiquitin ligase CUL-2 complex via NPL-4 binding to Elongin C. Furthermore, TRA-1A, which is the terminal effector of the sex determination pathway and is regulated by CUL-2-mediated proteolysis, accumulated in the cdc-48.1 mutant. Proteasome...

... condensation 1)-like repeats and a HECT (h omologous to E 6-AP C - t erminus) domain, representing a member of the HERC (HE CT and RC C1 domain protein) family of ubiquitin ligases. The mRNA level of this member, HERC5 , is specifically upregulated in endothelial cells by the pro-inflammatory cytokines tumor...

... importance for HBV biology remains open. The RING-H2 domain was functional in and essential for self- and trans-ubiquitylation in vitro and for proteasome-mediated turnover of the protein in vivo. We therefore termed it hRUL138 for human RNA-binding ubiquitin ligase of 138 kDa. hRUL138 mRNAs are expressed...

... the temperature sensitivity of pub1Δ cells, suggesting that the HECT domain of Pub2p has the catalytic activity of a ubiquitin ligase. We conclude that Pub2p is a HECT-type ubiquitin-protein ligase that shares partially overlapping function with Pub1p. References Alfa, C., Fantes, P., Hyams, J., McLeod, M...

... nuclei and chromosome bands at mitosis. βgeo Splicing Heterochromatin Kinase Ubiquitin ligase © 1998 by Company of Biologists 1998 29 06 1998 13 08 1998 * Present address: University of California, Department of Molecular and Cell Biology, Berkeley, CA 94720-3200...