... activation of the mitotic cyclin-dependent kinase (CDK) Cdc2 after UV irradiation. Furthermore, we demonstrate that translation of the mitotic cyclin Cdc13 is selectively downregulated after UV irradiation, and we propose that this downregulation of Cdc13 contributes to the delayed activation of Cdc2...

... is one of the key factors for TLS pathway choice. So far, it remains unclear how the TLS pathway is elaborately regulated. Here, we report that TLS polymerase REV1 can promote PCNA monoubiquitylation after UV radiation. Further studies revealed that this stimulatory effect is mediated through...

... modifications and chromatin accessibility to UV exposure remains poorly understood. Here, we report that UV exposure results in a genome-wide reduction in chromatin accessibility, while the distribution of the active regulatory mark H3K27ac undergoes massive reorganization. Genomic loci subjected to epigenetic...

... pathway in the DDR (by UV irradiation) and oncogenic stress (by H-RasV12) ( Aylon et al., 2009 ; Okada et al., 2011 ). In the oncogenic context, Lats2 induces apoptosis by diverting p53 from cell cycle gene promoters to pro-apoptotic gene promoters through phosphorylation of ASPP1 (apoptosis-stimulating...

...Daniël O. Warmerdam; Eva K. Brinkman; Jurgen A. Marteijn; René H. Medema; Roland Kanaar; Veronique A. J. Smits Summary In response to UV light, single-stranded DNA intermediates coated with replication protein A (RPA) are generated, which trigger the ATR-Chk1 checkpoint pathway. Recruitment...

...Mischa G. Vrouwe; Alex Pines; Rene M. Overmeer; Katsuhiro Hanada; Leon H. F. Mullenders Activation of signaling pathways by UV radiation is a key event in the DNA damage response and initiated by different cellular processes. Here we show that non-cycling cells proficient in nucleotide excision...

... of xenobiotics with electrophilic and oxidative properties and reduces the cell death induced by UV irradiation. In contrast to other cell types, cytoprotection of keratinocytes by KGF is not a direct anti-apoptotic effect but requires de novo protein synthesis. The in vitro findings are clinically relevant...

..., Ottawa, ON, K2B 7T6, Canada 8 11 2004 © The Company of Biologists Limited 2005 2005 PARP ADP-ribose UV DNA damage thymine dimers oxidative damage Ultraviolet B (UVB, 280-320 nm) is part of the terrestrial solar UV radiation that is implicated in sunlight induced non...

...Morten P. Oksvold; Henrik S. Huitfeldt; Anne Carine Østvold; Ellen Skarpen We have compared the activation and trafficking of epidermal growth factor receptor (EGFR) induced by UV light and EGF. Tyrosine phosphorylation of EGFR was not detected in UV-exposed cells by immunoblotting of whole cell...