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Keywords: USP7
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Journal Articles
Patricia Wilson, Lina Abdelmoti, Rebecca Norcross, Eun Ryoung Jang, Malathy Palayam, Emilia Galperin
Journal:
Journal of Cell Science
J Cell Sci (2021) 134 (21): jcs258922.
Published: 5 November 2021
... the functions of Shoc2 and its contributions to disease progression remain unclear. Here, we show that ERK1/2 pathway activation triggers the interaction of Shoc2 with the ubiquitin-specific protease USP7. We reveal that, in the Shoc2 module, USP7 functions as a molecular ‘switch’ that controls the E3 ligase...
Includes: Supplementary data
