... (UPR) remain unaltered in ScFIT mutants, SCS3 was found to be essential for proper stress-induced UPR activation and for viability in the absence of the sole yeast UPR transducer IRE1 . Owing to not having a functional UPR, cells with mutated SCS3 exhibited an accumulation of triacylglycerol within...

... the unfolded protein response (UPR) pathway, an evolutionarily conserved cell survival mechanism. Here, we show that mouse myoblasts respond to UPR activation by stimulating glycogenesis and the formation of α-amylase-degradable, glycogen-containing ER structures. We demonstrate that the glycogen-binding...

... composition. Perturbation of endoplasmic reticulum (ER) homeostasis through alteration in membrane phospholipids activates the unfolded protein response (UPR) and causes dramatic transcriptional and translational changes in the cell. To restore cellular homeostasis, the three highly conserved UPR transducers...

...Nir Cohen; Michal Breker; Anush Bakunts; Kristina Pesek; Ainara Chas; Josepmaria Argemí; Andrea Orsi; Lihi Gal; Silvia Chuartzman; Yoav Wigelman; Felix Jonas; Peter Walter; Robert Ernst; Tomás Aragón; Eelco van Anken; Maya Schuldiner ABSTRACT The unfolded protein response (UPR) allows cells...

... A was significantly more dynamic. In in vitro association studies, p.S143P lamin A failed to form appropriate filament structures but instead assembled into disorganized aggregates similar to those observed in patient cell nuclei. A whole-genome expression analysis revealed an elevated unfolded protein response (UPR...

... of Biologists Ltd 2016 Summary: ATF6a, a target of the Runx2 and Sox6 transcription factors, positively regulates hypertrophic chondrocyte differentiation and endochondral bone formation by acting as a coactivator of Runx2. ATF6a Chondrocyte hypertrophy UPR Transcription factor Regulation...

... (UPR) sensors ATF6 and IRE1 (also known as ERN1). Whereas ATF6 directly interacts with the E2F1 promoter, IRE1 requires the involvement of the known E2F1 modulator E2F7, through the activation of its main target Xbp-1. Importantly, inhibition of the E2F1 decrease prevents ER-stress-induced apoptosis...

...Amanda M. Preston; Linda M. Hendershot Summary The unfolded protein response (UPR) is a largely cytoprotective signaling cascade that acts to re-establish homeostasis of the endoplasmic reticulum (ER) under conditions of stress by inducing an early and transient block in general protein synthesis...

...Modi Safra; Shani Ben-Hamo; Cynthia Kenyon; Sivan Henis-Korenblit Summary The unfolded protein response (UPR) allows cells to cope with endoplasmic reticulum (ER) stress by adjusting the capacity of the ER to the load of ER-associated tasks. The UPR is important for maintaining ER homeostasis under...

... cell lines with cytokines involved in fibrogenesis (e.g. TGFβ1, AGT, PDGF) leads to ER-stress and UPR activation reflected by a substantial overexpression of ER-stress proteins (GRP78, GRP94, ERP57, ERP72, CALR). Alteration in the expression of ER-stress proteins and UPR function has an important role...

... to the ER-stress response also called unfolded protein response (UPR). Thus, parkin controls both endoplasmic reticulum and oxidative stresses ( Takahashi et al., 2003 ) and interacts with Hsp70 and some members of the ERAD (ER-associated degradation) machinery, Ubc7 and Ubc8 ( Tanaka et al., 2001...

...Patrick Lajoie; Erik L. Snapp Huntington's disease (HD) is caused by expanded glutamine repeats within the huntingtin (Htt) protein. Mutant Htt (mHtt) in the cytoplasm has been linked to induction of the luminal endoplasmic reticulum (ER) stress pathway, the unfolded protein response (UPR). How...

... Endoplasmic reticulum Unfolded protein response UPR Thyroglobulin Chaperone Specialized secretory cells have a well-developed pathway for transport of proteins out of the cell. Proteins destined for secretion need to fold into their native structure in the endoplasmic reticulum (ER), the first...

... –/– or WT MEFs, suggesting that an autophagic response is associated but not relevant for thapsigargin-induced cell death. Another mechanism by which the UPR could impact on cell death is the IRE1α pathway. Bak/Bax were suggested to directly interact with IRE1α resulting in activation of JNK ( Hetz et...

...Karsten Gülow; Detlef Bienert; Ingrid G. Haas The lumenal endoplasmic reticulum (ER) protein BiP, among its other functions, is believed to serve as an ER stress sensor, triggering the so-called `unfolded protein response' or UPR. For this role, BiP levels are critical. Indeed, here we show...