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1-18 of 18
Keywords: Tyrosine kinase
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Journal Articles
Helena L. Palka-Hamblin, Jessica J. Gierut, Wenjun Bie, Patrick M. Brauer, Yu Zheng, John M. Asara, Angela L. Tyner
Journal:
Journal of Cell Science
J Cell Sci (2010) 123 (2): 236–245.
Published: 15 January 2010
...Helena L. Palka-Hamblin; Jessica J. Gierut; Wenjun Bie; Patrick M. Brauer; Yu Zheng; John M. Asara; Angela L. Tyner Disruption of the gene encoding protein tyrosine kinase 6 (PTK6) leads to increased growth, impaired enterocyte differentiation and higher levels of nuclear β-catenin in the mouse...
Journal Articles
Camille Faure, Jean-Christophe Corvol, Madeleine Toutant, Emmanuel Valjent, Øivind Hvalby, Vidar Jensen, Said El Messari, Jean-Marc Corsi, Gress Kadaré, Jean-Antoine Girault
Journal:
Journal of Cell Science
J Cell Sci (2007) 120 (17): 3034–3044.
Published: 1 September 2007
...Camille Faure; Jean-Christophe Corvol; Madeleine Toutant; Emmanuel Valjent; Øivind Hvalby; Vidar Jensen; Said El Messari; Jean-Marc Corsi; Gress Kadaré; Jean-Antoine Girault Proline-rich tyrosine kinase 2 (PYK2) is a non-receptor tyrosine kinase expressed in many cell types and enriched in neurons...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2002) 115 (15): 3039–3048.
Published: 1 August 2002
...Aya Takesono; Lisa D. Finkelstein; Pamela L. Schwartzberg The Tec kinases represent the second largest family of mammalian non-receptor tyrosine kinases and are distinguished by the presence of distinct proline-rich regions and pleckstrin homology domains that are required for proper regulation...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2002) 115 (3): 455–465.
Published: 1 February 2002
... function as GPCR signal transducers. They can form complexes with several signaling proteins,including Src family tyrosine kinases and components of the ERK1/2 and JNK3 MAP kinase cascades. By recruiting these kinases to agonist-occupied GPCRs,β-arrestins confer distinct signaling activities upon...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2001) 114 (14): 2553–2560.
Published: 15 July 2001
... pathway may provide a paradigm for understanding how cell adhesion can determine cell cycle progression. © The Company of Biologists Limited 2001 2001 Tyrosine kinase Signal transduction Growth control Cell adhesion Proliferation of mammalian cells is tightly regulated by multiple...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2001) 114 (10): 1925–1934.
Published: 15 May 2001
... to collagen IV. * Author for correspondence (e-mail: [email protected] ) 03 02 2001 © 2001 by Company of Biologists 2001 Actin α-catenin LTD 4 PKC-α Tyrosine kinase Vinculin Formation of epithelial barriers is highly dependent on physical interactions...
Journal Articles
Heinz Schmitz, Michael Fromm, Carl J. Bentzel, Peter Scholz, Katharina Detjen, Joachim Mankertz, Hagen Bode, Hans-Jörg Epple, Ernst-Otto Riecken, Jörg-Dieter Schulzke
Journal:
Journal of Cell Science
J Cell Sci (1999) 112 (1): 137–146.
Published: 1 January 1999
... 4.7 to 3.4. The tyrosine kinase blocker genistein and the protein kinase A inhibitor H-8 reduced the effect of TNFα. A combination of TNFα with interferon-γ acted synergistically on the epithelial barrier. In conclusion, TNFα impairs epithelial barrier function by altering structure and function...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1996) 109 (6): 1335–1346.
Published: 1 June 1996
... in vitro, and also express a temperature-sensitive mutant of the v-Src tyrosine kinase that allows the control of differentiation in a reversible manner. By immunofluorescence and electron microscopy we show that v-Src activity in myotubes leads to an extensive cellular remodeling which affects components...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1996) 109 (4): 851–858.
Published: 1 April 1996
...Giovanna Berruti; Barbara Borgonovo ABSTRACT sp42, a tyrosine kinase of 42 kDa originally found in ejaculated boar spermatozoa, is so far the only tyrosine protein kinase to have been purified from mature male germ cells. We have developed and characterized rabbit polyclonal antibodies specifically...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1995) 108 (1): 225–233.
Published: 1 January 1995
... by the platelet-derived growth factor and insulin receptors. The effects of lysophosphatidic acid on the Swiss 3T3 actin cytoskeleton can be blocked by the tyrosine kinase inhibitor, tyrphostin. Since tyrphostin does not inhibit the effects of microinjected rho protein, we conclude that lysophosphatidic acid...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1994) 107 (3): 417–425.
Published: 1 March 1994
... FGF receptor tyrosine kinase mesenchyme condensation brain development amphibian During the last few years significant progress has been made in the understanding of mechanisms of mesoderm formation in amphibian embryos, primarily due to the discovery that peptide growth factors belonging...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1994) 1994 (Supplement_18): 121–126.
Published: 1 January 1994
...Lewis C. Cantley; Zhou Songyang ABSTRACT SH2 domains and SH3 domains, found in a number of protein-tyrosine kinases and substrates of protein-tyrosine kinases, provide specificity in downstream signaling. Both of these domains bind to relatively short linear sequences of peptides to provide...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1993) 106 (4): 1211–1220.
Published: 1 December 1993
... was phosphorylated on serine and tyrosine residues, suggesting that the activation of protein kinase C also stimulated tyrosine kinase activity. p37 did not precipitate with annexin I or II antibodies. These results show that sheep tracheal cilia contain protein kinase C activity and that activated protein kinase C...
Journal Articles
Curt M. Horvath, Amy Wolven, Debbie Machadeo, Julie Huber, Lana Boter, Marta Benedetti, Barbara Hempstead, Moses V. Chao
Journal:
Journal of Cell Science
J Cell Sci (1993) 1993 (Supplement_17): 223–228.
Published: 1 December 1993
..., and NT-5. These neurotrophin factors interact with two classes of receptors, the trk receptor tyrosine kinase family, and the low affinity p75 neurotrophin receptor. To study potential ligand-receptor interactions, recombinant trk fusion proteins have been constructed, and pan-Zrft polyclonal antisera...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1993) 105 (3): 629–636.
Published: 1 July 1993
... was investigated by western blot analysis and its tyrosine kinase activity was measured concomitantly. In mononuclear cytotrophoblasts, pp60 c- src was localized at cell-matrix contacts and during the aggregation of cytotrophoblasts, pp60 c- src was distributed on the cell surface at points of cell-cell contact...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1991) 100 (4): 815–824.
Published: 1 December 1991
... is not sufficient for activation of motility. Activation of motility in vitro by incubation with cyclic AMP can be completely inhibited by a random copolymer of glutamate and tyrosine that inhibits tyrosine kinase activity. Under these conditions, much of the protein phosphorylation associated with activation...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1991) 99 (2): 207–211.
Published: 1 June 1991
... is associated with tyrosine phosphorylation, the signal transduction pathways and the mechanism by which oncogenic tyrosine kinases induce cell growth and neoplastic changes remain elusive ( Jove and Hanafusa, 1987 ; Yarden and Ullrich, 1988 ). The acutely transforming avian sarcoma viruses have been invaluable...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1989) 93 (4): 667–674.
Published: 1 August 1989
...-containing proteins and protein kinase activities that phosphorylate tyrosine residues in a mammalian mature spermatozoon. * Author for correspondence 21 02 1989 09 05 1989 © 1989 by Company of Biologists 1989 spermatozoa tyrosine-phosphorylated proteins tyrosine kinase...