... and efficacy of tumor cell migration. CAFs are known to increase invasion of less-aggressive breast cancer cells through matrix remodeling and leader–follower dynamics. Here, we demonstrate that CAFs communicate with breast cancer cells through the formation of contact-dependent tunneling nanotubes (TNTs...

...Seng Zhu; Shaarvari Bhat; Sylvie Syan; Yoshihiko Kuchitsu; Mitsunori Fukuda; Chiara Zurzolo ABSTRACT Tunneling nanotubes (TNTs) are actin-enriched membranous channels enabling cells to communicate over long distances. TNT-like structures form between various cell types and mediate the exchange...