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Keywords: Tumour suppressionClose
J Cell Sci (2011) 124 (11): 1785–1793.
Published: 1 June 2011
... of sensitivity to ErbB-targeted therapeutics. Although the LRIG1 gene maps to chromosome 3p14, a region frequently deleted in human tumours, conclusive genetic evidence implicating a role for LRIG1 in tumour suppression is not yet available. Nevertheless, a number of reports suggest that loss of LRIG1...
Includes: Supplementary data
J Cell Sci (2001) 114 (20): 3591–3598.
Published: 15 October 2001
... biological role that explains tumour suppression by the BRCA proteins? At least in the case of BRCA1, cancer-associated mutations affecting a number of different regions spanning the length of the protein have the common property of being unable to reconstitute DSB repair when expressed in BRCA1-deficient...
J Cell Sci (1994) 1994 (Supplement_18): 1–5.
Published: 1 January 1994
... of Biologists Limited 1994 1994 Wilms’ tumour WT1 transcriptional repression tumour suppression zinc finger ...
J Cell Sci (1988) 1988 (Supplement_10): 171–180.
Published: 1 February 1988
... the fragmentary but firm evidence that shows the existence of such mechanisms. Tumour-suppressing genes have been detected in the following systems: (i) Fusion of normal and malignant cells leads to the suppression of the tumorigenic phenotype in the majority of the combinations where the hybrid maintains...