... Lange, 2017 ; Shay and Wright, 2010 ). Additionally, an aged microenvironment containing cells with dysfunctional telomeres can induce loss of quiescence and tumorigenesis ( Lex et al., 2020 ; Song et al., 2012 ). Quiescence not only protects telomeres from attrition by restraining proliferation...

... development in mice. We propose that wild-type p53 amyloid formation contributes to tumorigenesis and can be a potential target for therapeutic intervention. This article has an associated First Person interview with the first author of the paper. The statistical significance [* P <0.05, ** P <0.01...

...-dependent suppression of PAR3 (encoded by PARD3 ) accelerates epithelial disorganization during early tumorigenesis. Diminished PAR3 led to loss of E-cadherin-mediated cell adhesion, which in turn contributed to misoriented cell division. Pharmacological inhibition of the MAPK pathway downstream of RAS...

... impact on genetic biodiversity in mammals. The tumor suppressor TP53 gene (encoding p53) plays an important role in the regulation of tumorigenesis in hepatocellular carcinoma (HCC). Δ40p53α is a naturally occurring p53 isoform that lacks the N-terminal transactivation domain, yet little is known about...

...Riccardo Maurelli; Lavinia Tinaburri; Fabio Gangi; Sergio Bondanza; Anna Lisa Severi; Claudia Scarponi; Cristina Albanesi; Giuseppe Mesiti; Liliana Guerra; Maurizio C. Capogrossi; Elena Dellambra ABSTRACT The role of Ras in human skin tumorigenesis induction is still ambiguous. Overexpression...

... ). However, although a consistent body of correlative evidence is building, the mechanistic causes of these links remain to be established. Drosophila melanogaster Haematopoiesis Tumorigenesis JAK Rho1 © 2014. Published by The Company of Biologists Ltd 2014 This is an Open Access...

...   L. , He   C. , Yang   B. B. ( 2011 ). Expression of CD44 3′-untranslated region regulates endogenous microRNA functions in tumorigenesis and angiogenesis . Nucleic Acids Res.   39 , 3026 - 3041 . Jiang   H. , Peterson   R. S. , Wang   W. , Bartnik   E. , Knudson   C. B...

...Youping Sun; Malgorzata Klauzinska; Robert J. Lake; Joseph M. Lee; Stefania Santopietro; Ahmed Raafat; David Salomon; Robert Callahan; Spyros Artavanis-Tsakonas Notch receptors and their ligands have crucial roles in development and tumorigenesis. We present evidence demonstrating the existence...

...Yujin Zhang; Mindy K. Call; Lung-Kun Yeh; Hongshan Liu; Tyler Kochel; I-Jong Wang; Pao-Hsien Chu; Makoto M. Taketo; James V. Jester; Winston W.-Y. Kao; Chia-Yang Liu β-catenin signaling has been shown to play a fundamental role in embryonic development and tumorigenesis. In this study, we...

... to suppress tumour incidence ( Yan et al., 1997 ). Also, crossing of Id3 − / − mice with mice lacking the related bHLH protein, HEB, leads to T cell tumorigenesis not seen in individual single-knockout animals ( Barndt and Zhuang, 1999 ). Although the etiological mechanisms involved are unclear...

... − cells to form sarcomas and to understand whether suppression of TTL activity is directly related to tumorigenesis. We have conducted a limited survey of primary human breast tumors and have found that almost all suppress TTL activity. A broad survey of human tumors to determine the frequency of TTL...

...-mail: [email protected] ) 29 08 1996 11 02 1997 © 1997 by Company of Biologists 1997 Simple keratin Tumorigenesis Keratin induction Intermediate filament proteins are expressed in a tissue specific pattern in vivo, and are believed to have a role related to very...

... carry mainly intact syndecan molecules but when cells are stimulated to migrate (e.g. during wound healing or tumorigenesis; Elenius et al., 1991 ; Inki et al., 1991 ), they loosen their attachment by cleaving the ectodomains with the help of pericellular proteases. The most obvious differences...

... tumorigenesis HSV upregulation pathogenesis A component of the herpes simplex virus (HSV) virion (UL41) can shut off the majority of host cell synthesis ( Fenwick and Walker, 1978 ; Fenwick and Everett, 1990 ); efficiency varies in different virus strains. Some genes are not switched off ( Kemp et al...

... and tumorigenic cells is not known. Here we have explored further the relationship between the expression of EDIIIA+ and EDIIIB+ FNs and tumorigenesis by the use of human somatic cell hybrids made from the fusion of normal fibroblasts and fibrosarcoma-derived cells. Our analyses of GM00097 and HT1080 parent cells...