.... This supports potential roles for TNC in immunity control. Advances using murine models with engineered TNC levels were instrumental in the discovery of important functions of TNC as a danger-associated molecular pattern (DAMP) molecule in tissue repair and revealed multiple TNC actions in tumor progression...

...Sreeja V. Nair; Nikhil Dev Narendradev; Rithwik P. Nambiar; Rakesh Kumar; Srinivasa M. Srinivasula ABSTRACT Lysosomal exocytosis and resealing of damaged plasma membrane are essential for cellular homeostasis and tumor invasion. However, very little is known of the molecular machinery...

..., their roles in physiological and pathological settings with special emphasis on wound healing, fibrosis and tumor–stroma interactions, and include a discussion of the most recently identified newcomers to this subfamily – integrins α10β1 and α11β1. * Author for correspondence ( [email protected]...

...Gabriel M. Gordon; Tianyi Zhang; Jiong Zhao; Wei Du Summary Synthetic lethality is a potential strategy for cancer treatment by specifically promoting the death of cancer cells with particular defects such as the loss of the RB ( RB1 ) tumor suppressor. We previously showed that inactivation...

... populations of neoplastic adrenocortical cells form: non-steroidogenic LH-independent A cells and steroidogenic LH-dependent B cells. * Author for correspondence ( [email protected] ) 31 12 2012 © 2013. Published by The Company of Biologists Ltd 2013 GATA-4 Adrenal Tumor...

... responses, and tumor progression. Semaphorin receptors, the neuropilins and the plexins, are expressed by a wide variety of cell types, including endothelial cells, bone-marrow-derived cells and cancer cells. Interestingly, a growing body of evidence indicates that semaphorins also have an important role...

... mutations produce a synergistic effect that is sufficient to transform normal colonic epithelial cells and render them tumorigenic ( D'Abaco et al., 1996 ). Individuals exhibiting ras mutations are resistant to tumor development in the presence of normal Apc , suggesting that the ability of Apc...

...-late-replicating loci. We analyzed diploid human, non-human primate and rearranged tumor cells by 3D fluorescence in situ hybridization with the aim of investigating the impact of chromosomal structural changes on the nuclear organization of these loci. Overall, their topology was found to be largely...

... of breast epithelial cells and breast and colon carcinoma cells to forces imposed by laminar flow in a parallel plate flow channel was examined. Although E-cadherin negative tumor cells formed cell aggregates in the presence of calcium, these were significantly more likely than E-cadherin positive cell...

...Andrew P. Feinberg ABSTRACT Wilms’ tumor has served as an example of Knudson’s two- hit hypothesis of recessive tumor genes, but the genetics has proven to be surprisingly complex. WTI, a tumor sup- pressor gene on llpl3, is mutated in only a small fraction of Wilms’ tumors, and a second...